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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SUMMER 2011 , Volume 2 , Number 4; Page(s) 53 To 57.
 
Paper: 

MODULATION OF ANXIETY-LIKE BEHAVIOR IN SILDENAFIL CITRATE-TREATED MICE PLACED IN AN ELEVATED PLUS-MAZE

 
 
Author(s):  SHAHIDI SIAMAK, HASHEMI FIROUZI NASRIN*, MAHMOODI MINOO
 
* DEPARTMENT OF BIOLOGY, ISLAMIC AZAD UNIVERSITY, HAMADAN BRANCH, HAMADAN, IRAN
 
Abstract: 

Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO) -cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior in mice.
Methods: Male mice were intraperitoneally (i.p.) administrated sildenafil (1, 2, or 10 mg/kg), and the control group was given the vehicle 15 min before the plus-maze test. The number of entries into the open arms of the plus-maze, the time spent in the open arms, and the total numbers of entries into the arms were recorded.
Results: The results indicated that compared to the control group, the sildenafiltreated mice spent more time in the open arms and had a greater number of entries into open arms. The total number of entries into the arms did not significantly differ between the sildenafil-treated groups and the control group.
Discussion: Acute administration of sildenafil could have anxiolytic effects on male mice. This effect might be mediated in a time-dependent manner by the NO/cGMP/PDE5 pathway.

 
Keyword(s): ANXIETY, SILDENAFIL, ACUTE, ELEVATED PLUS-MAZE, MICE
 
 
References: 
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Click to Cite.
APA: Copy

SHAHIDI, S., & HASHEMI FIROUZI, N., & MAHMOODI, M. (2011). MODULATION OF ANXIETY-LIKE BEHAVIOR IN SILDENAFIL CITRATE-TREATED MICE PLACED IN AN ELEVATED PLUS-MAZE. BASIC AND CLINICAL NEUROSCIENCE, 2(4), 53-57. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276227



Vancouver: Copy

SHAHIDI SIAMAK, HASHEMI FIROUZI NASRIN, MAHMOODI MINOO. MODULATION OF ANXIETY-LIKE BEHAVIOR IN SILDENAFIL CITRATE-TREATED MICE PLACED IN AN ELEVATED PLUS-MAZE. BASIC AND CLINICAL NEUROSCIENCE. 2011 [cited 2021May06];2(4):53-57. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276227



IEEE: Copy

SHAHIDI, S., HASHEMI FIROUZI, N., MAHMOODI, M., 2011. MODULATION OF ANXIETY-LIKE BEHAVIOR IN SILDENAFIL CITRATE-TREATED MICE PLACED IN AN ELEVATED PLUS-MAZE. BASIC AND CLINICAL NEUROSCIENCE, [online] 2(4), pp.53-57. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276227.



 
 
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