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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SUMMER 2011 , Volume 2 , Number 4; Page(s) 47 To 52.
 
Paper: 

CHRONIC TREATMENT BY L-NAME DIFFERENTLY AFFECTS MORRIS WATER MAZE TASKS IN OVARIECTOMIZED AND NAIVE FEMALE RATS

 
 
Author(s):  HOSSEINI MAHMOUD*, FEIZPOUR AZADEH, REZAEIPOUR MOHSEN, AMANI ATEFEH, SAFFARZADEH FATIMA, FARROKHI ESMAEIL
 
* DEPT. OF PHYSIOLOGY, MEDICAL SCHOOL, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD, IRAN
 
Abstract: 

Introduction: The role of ovarian hormones and nitric oxide (NO) in learning and memory and their interaction has been widely investigated. The present study carried out to evaluate different effect of L-NAME on spatial learning and memory of ovariectomized (OVX) and sham operated rats.
Methods: 32 rats were divided into 4 groups: 1) Sham; 2) OVX; 3) Sham-LN; and 4) OVX-LN. The animals of groups 3 and 4 were treated by L-NAME (10 mg/kg/ day) for 8 weeks while the animals of groups 1 and 2 received saline (1ml/kg/day) instead of L-NAME. The animals of all groups were then tested in Morris water maze during five days. The escape latency and traveled distance were compared between groups.
Results: Distance and time in OVX group was significantly higher than Sham group (p<0.01 and p<0.05). Time and distance in Sham-LN group was higher in comparison with Sham group (p<0.05 and p<0.01). There were no significant differences between OVX-LN and OVX groups in escape latency and traveled distance.
Discussion: The results of present study showed that removal of ovarian hormones could impair Morris water maze tskas includiong time and distance. Administarion of non specific nitricoxide inhibitor, L-NAME, affects Morrsi water maze tasks however, its effect is different in the absence and presence of ovarian hormones but it needs to be more investigated.

 
Keyword(s): OVARIECTOMY, FEMALE RAT, MORRIS WATER MAZE, L-NAME
 
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