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Paper Information

Journal:   BASIC AND CLINICAL NEUROSCIENCE   SUMMER 2011 , Volume 2 , Number 4; Page(s) 5 To 11.
 
Paper: 

THE POWER OF CLASSIC MUSIC TO REDUCE ANXIETY IN RATS TREATED WITH SIMVASTATIN

 
 
Author(s):  DA CRUZ JULIA NIEHUES, DE LIMA DANIELA DELWING, DAL MAGRO DEBORA DELWING, DA CRUZ JOSE GERALDO PEREIRA*
 
* REGIONAL UNIVERSITY OF BLUMENAU DEPARTMENT OF NATURAL SCIENCES, UNIVERSIDADE REGIONAL DE BLUMENAU, RUA ANTONIO DA VEIGA, 140, BRAZIL
 
Abstract: 

Introduction: This study was designed to investigate the effects of music in Wistar rats after sub-chronic treatment of simvastatin.
Methods: The rats were orally administered with either simvastatin or saline (controls). After 4 weeks of drug treatment, the rats were selected for behavioral studies. The rats were exposed to music 24 hours before behavioral tests (Mozart’s piano sonata, KV361, Largo).
Results: The experiments suggest that exposure to chronic treatment with simvastatin (1 or 10 mg/kg/day) reduced anxiety levels in rats when associated with Mozart music in an elevated plus-maze.
Discussion: These results indicate that music can serve as an effective adjuvant in rats treated with simvastatin, and that this species could potentially be used in other preclinical models utilizing musical interventions.

 
Keyword(s): MUSIC, ELEVATED PLUS-MAZE, OPEN-FIELD, RATTUS NORVEGICUS, SIMVASTATIN
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

DA CRUZ, J., & DE LIMA, D., & DAL MAGRO, D., & DA CRUZ, J. (2011). THE POWER OF CLASSIC MUSIC TO REDUCE ANXIETY IN RATS TREATED WITH SIMVASTATIN. BASIC AND CLINICAL NEUROSCIENCE, 2(4), 5-11. https://www.sid.ir/en/journal/ViewPaper.aspx?id=276193



Vancouver: Copy

DA CRUZ JULIA NIEHUES, DE LIMA DANIELA DELWING, DAL MAGRO DEBORA DELWING, DA CRUZ JOSE GERALDO PEREIRA. THE POWER OF CLASSIC MUSIC TO REDUCE ANXIETY IN RATS TREATED WITH SIMVASTATIN. BASIC AND CLINICAL NEUROSCIENCE. 2011 [cited 2021July30];2(4):5-11. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276193



IEEE: Copy

DA CRUZ, J., DE LIMA, D., DAL MAGRO, D., DA CRUZ, J., 2011. THE POWER OF CLASSIC MUSIC TO REDUCE ANXIETY IN RATS TREATED WITH SIMVASTATIN. BASIC AND CLINICAL NEUROSCIENCE, [online] 2(4), pp.5-11. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=276193.



 
 
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