Paper Information

Journal:   IRANIAN JOURNAL OF NEUROLOGY   SPRING-SUMMER 2007 , Volume 6 , Number 17-18; Page(s) 39 To 48.
 
Paper:  EVALUATION THE EFFECT OF BLOCKAGE GAP JUNCTIONS ON ISCHEMIC DAMAGES AND EDEMA IN EXPERIMENTAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA IN RAT
 
Author(s):  VAKILI ABEDIN, HOSSEINIZADEH SAYED AHMAD, ZAHEDI KHORASANI MEHDI
 
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Abstract: 
Introduction: Gap junctions are inter-cellular communicative channels that have been reported controversial results about role of them in cerebral ischemia. Recently have shown that carbenoxolone (CBX, a potent gap junction blocker) significantly reduces neuronal cell death in global cerebral ischemia.
However, role of gap junction with using of CBX has not been investigated in transient model of focal cerebral ischemia.
Material and methods: Transient focal cerebral ischemia was induced via filament method in rats by 1 hour middle cerebral artery occlusion (MCAO), followed by 23 h reperfusion. CBX was administered (200 mg/kg ip) at the beginning of ischemia. Infarct volume, brain edema and neurological motor dysfunction were assessed 24 h after MCAO.
Results: Administration of CBX (200 mg/kg ip) at the beginning of ischemia significantly reduces cortical and striatal infarct volumes by 58% and 63%, respectively in comparison with control group (P<0.001). CBX did not significantly change brain edema or neurological dysfunction (P>0.05).
Conclusion: Results of this study indicate that administration systemic of CBX reduces ischemic injuries in early phase of transient focal cerebral ischemia in rat. These findings also indicate that gap junction may have involved in development of brain damage in transient focal cerebral ischemia.
 
Keyword(s): CARBENOXOLONE, GAP JUNCTION BLOCKER, BRAIN EDEMA, TRANSIENT FOCAL CEREBRAL ISCHEMIA, RAT
 
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