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Paper Information

Journal:   IRANIAN JOURNAL OF NEUROLOGY   SPRING-SUMMER 2007 , Volume 6 , Number 17-18; Page(s) 31 To 38.
 
Paper: 

STUDY ON INCIDENCE OF LEVODOPA INDUCED DYSKINESIA IN PARKINSONS PATIENTS

 
 
Author(s):  PASHAPOUR ALI, CHARSUEE SAEED, SADRODINI SEYED ALI, POURREZA PEIMAN, PASHAPUR SANAZ
 
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Abstract: 
Background and objective: Parkinson's disease (PD) is one of the most common neurodegenerative disease in world wide. Dopaminergic neural death in substantianigra is subsequently found to be the main pathologic process leading cause to motor disability. For the treatment of this disease many drugs applied, but levodopa was the first and is still a highly effective drug for symptomatic treatment of Parkinson's disease.
Administration of levodopa is associated with a decrease in mortality compared to the pre levodopa treatment.
However, chronic use of levodopa is associated with certain limitation including of motor complication in the majority of patients. The most common motor complications are drug-induced dyskinesia and these problems can seriously compromise function and limit the patient's ability to benefit fully from the drug.
Conclusion: There are 3 important factors found which could predict future development of Levodopa advers effects. There were: daily Levodopa dosage, age of onset and duration of disease. So that, for decreases of the risk of levodopa-induced dyskinesia we can: decrease the levodopa dosage, to put of the levodopa usage and use other effective therapy such as Dopamine agonist.
Materials and Methods: This study was a descriptive and cohort study that comprised 60 patients referred to neurological clinic with Parkinsonism. Our study aimes included to determine the frequency of dyskinesia and dosage of levodopa and time of beginning of dyskinesia and the location of dyskinesia in the body. Statistical analysis were used SPSS and statistical significance defined as a p- value<0.05.
Results: A total 60 Parkinson’s disease patients were participated in the present study, 49 patients were male and 21 patients female with average age 66.45 years old. The key features of Parkinson's disease which were bradykinesia, rigidity and tremor were present in almost patients.
There were 11 cases of dyskinesia with frequency of 36%, 6 men and 5 women, the dosage of levodopa in patients with dyskinesia was 620 mg / day and 550 mg/day in patients without dyskinesia. The average time of incidence of dyskinesia after used the levodopa in patients was 5 years later. The average age of onset in patients with dyskinesia was 59 Years (less than patient without dyskinesia). And the common location of dyskinesia was or omandibular (9 cases of 11 cases).
 
Keyword(s): LEVODOPA. OROMANDIBULAR DYSKINESIA, PARKINSON
 
References: 
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