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Paper Information

Journal:   JOURNAL OF MEDICAL COUNCIL OF I.R.I.   FALL 2007 , Volume 25 , Number 3; Page(s) 373 To 378.
 
Paper: 

EARLY ONSET CHORIOCARCINOMA AFTER TERM PREGNANCY (CASE REPORT)

 
 
Author(s):  GHAEM MAGHAMI F.*, KARIMI ZARCHI M., MODARRES GILANI M., MOUSAVI A.
 
* DEPT. OF OBSTETRICS AND GYNECOLOGY, VALI-ASR HOSPITAL, IMAM KHOMEINI HOSPITAL COMPLEX, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Choriocarcinoma is a curable malignancy that occurs after term pregnancy in approximately 50% of cases, and prognosis of this form of gestational trophoblastic neoplasm (GTN) is poor. The earliest onset of choriocarcinoma after term pregnancy was reported 3 weeks after delivery in one study, but in the current study, choriocarcinoma was diagnosed 2 weeks after delivery.
In 2004, a 28 year-old woman (gravidity 2, parity 2) delivered a healthy infant at term. Frequent episodes of vaginal bleeding occurred after 10 days of delivery. On admission to Vali-Asr Hospital, she had lesions in the lungs. The pretreatment
b-HCG level was 84000 mIU/ml and her score was 8 (high risk group). The EMA/CO regimen was administered as first line chemotherapy and patient achieved complete remission after 7 courses of therapy.
Although early onset postpartum hemorrhage is mostly due to complications of delivery, but gestational trophoblastic disease (GTD) should be considered and assessment of
b-HCG could be of help in the early diagnosis of GTD.

 
Keyword(s): GESTATIONAL TROPHOBLASTIC DISEASE, CHORIOCARCINOMA, VAGINAL BLEEDING AFTER DELIVERY, TERM PREGNANCY, OUTCOME
 
References: 
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