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Paper Information

Journal:   MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY   FALL 2012 , Volume 22 , Number 3 (69); Page(s) 168 To 174.
 
Paper: 

THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS

 
 
Author(s):  YAGHMAEI PARICHEHR*, HAYATI RUDBARI NASIM, SARKANI FUZIEH
 
* DEPARTMENT OF BIOLOGY, FACULTY OF BASIC SCIENCES, ISLAMIC AZAD UNIVERSITY, SCIENCE AND RESEARCH CAMPUS, TEHRAN, IRAN
 
Abstract: 

Background: The aim of this study was to evaluate the sequence effects of simvastatin and fatigue, specifically the interaction between fatigue effects and passive avoidance learning in simvastatin treated rats.
Materials and methods: In this experimental study, 40 male Wistar rats weightening 300-350 g were divided into 4 groups: control group: treated with enough tap (n=10), Sham group: rats which were gavaged with distilled water and food (n=10), first experimental (Exp1) and Second experimental (Exp2) group: rats which were gavaged with distilled water and food (n=10) and simvastatin with dose of 1 mg/kg for 35 days (n=10). Then, both experimental groups were forced to swim in aquariums for 35 days at 9-10 AM to 13-14 PM. At the end of treatment days, passive avoidance learning (PAL) system was considered and monitored. The learning and memory of all groups were studied. After performing behavioral tests, testosterone and cortisol were measured.
Results: fatigue decreased learning activity in Exp group one (P<0.001), while simvastatin causes increase in learning actitives in Exp group two. Also, fatigue induced by forced swimming caused significant decrease of testosterone hormone level (P<0.001), increase of cortisole hormone level (P<0.001) in experimental groups in comparison with sham and control groups.
Conclusion: Our study showed that fatigue due to long term swimming causes decrease in learning, while simvastatin drug is effective for prevention of decrease of learning and memory in fatigued rats.

 
Keyword(s): FATIGUE, PASSIVE AVOIDANCE LEARNING, SIMVASTATIN, MALE RAT
 
 
References: 
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Citations: 
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APA: Copy

YAGHMAEI, P., & HAYATI RUDBARI, N., & SARKANI, F. (2012). THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(3 (69)), 168-174. https://www.sid.ir/en/journal/ViewPaper.aspx?id=275909



Vancouver: Copy

YAGHMAEI PARICHEHR, HAYATI RUDBARI NASIM, SARKANI FUZIEH. THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY. 2012 [cited 2021July29];22(3 (69)):168-174. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275909



IEEE: Copy

YAGHMAEI, P., HAYATI RUDBARI, N., SARKANI, F., 2012. THE EFFECT OF FATIGUE ON PASSIVE AVOIDANCE LEARNING AND ITS INTERACTION WITH SIMVASTATIN DRUG IN MALE WISTAR RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, [online] 22(3 (69)), pp.168-174. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275909.



 
 
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