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Paper Information

Journal:   JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN)   SPRING 2011 , Volume 1 , Number 3; Page(s) 41 To 47.
 
Paper: 

EFFECT OF ADDING KETAMINE TO PETHIDINE ON POSTOPERATIVE PAIN IN MAJOR ABDOMINAL OPERATIONS

 
 
Author(s):  NOUROZI AFSANEH, TALEBI HOUSHANG*, FATEH SHAHIN, MOHAMMADZADEH ALI, AHMADI ZOHREH, SAVARABADI AKRAM, MOHEBBI ATEFEH
 
* DEPARTMENT OF ANESTHESIOLOGY, ARAK UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background and aim: Prescribing high doses of analgesics for pain relief after major abdominal surgeries are accompany with side effects. Thus, introducing adjunct drugs to be able to reduce the required dose of opioids would have great clinical relevance. The aim of this study was to determine the effect of adding ketamine to pethidine in reducing post-operative pain in patients undergoing major abdominal operations.
Methods: In this study, 100 patients aged 15-60 years who were candidate for elective major abdominal surgery allocated into two groups of pethidine+ketamine group (5 mg pethidine and 0.25 mg/kg ketamine) or pethidine and placebo group (10 mg pethidine and NS) according to the regimen prescribed in postanesthesia care unit. Severity of pain (using visual analogue scale), prescribed dose of pethidine, and side effects were recorded until 24 hours after operation.
Results: regarding post-operative pain, pethidine+ketamine group showed significant lower scores in all the times except 0 min, 2 h, 6 h, and 16 h. Nausea was significantly less frequent amongst pethidine+placebo group at times of 0, 15, 30, and 45 min (P<0.05). Comparison of two groups did not show significant differences in prescribed pethedine dose in 0, 9 h, 12 h, 16 h, 20 h, and 24 h (P>0.05). Yet, the mean dose of administered pethidine as rescue analgesic was significant lower in pethidine+ketamine group compared to pethidine+placebo group (112±31.5 mg vs.133.5±24.5 mg, P<0.001).
Conclusions: This study showed that co-administration of ketamine and pethidine will improve postoperative pain and reduce narcotic consumption. It may, however, increase rate of postoperative nausea in the first hour after operation.

 
Keyword(s): KETAMINE, PETHIDINE, POSTOPERATIVE PAIN, NAUSEA
 
References: 
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