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Paper Information

Journal:   IRANIAN HEART JOURNAL (IHJ)   SPRING 2012 , Volume 13 , Number 1; Page(s) 34 To 39.
 
Paper: 

ORAL FLECAINIDE IS NOT SENSITIVE ENOUGH TO RULE OUT BRUGADA-SYNDROME

 
 
Author(s):  HASHEMI ARASH, SHAHRZAD SHAHAB, SHAHRZAD SORAYA, HASHEMI M.J., SABER SIAMAK, TABAN SAMIRA, HASHEMI ASHKAN, ASLANI AMIR, EMKANJOO ZAHRA*
 
* DEPARTMENT OF PACEMAKER AND ELECTROPHYSIOLOGY RAJAEE CARDIOVASCULAR MEDICAL AND RESEARCH CENTER TEHRAN, IRAN
 
Abstract: 
Objectives: The Brugada syndrome is a heterogeneous genetic disease that predisposes one to life-threatening ventricular tachyarrhythmia and sudden cardiac death (SCD). In this study, we sought to compare the efficacy of intravenous Procainamide versus oral Flecainide to unmask the typical electrocardiographic changes of this syndrome.
Methods: From October 2001 to December 2010, we evaluated patients with the Brugada Type Electrocardiographic (ECG) pattern. In these patients, 104 patients (83%) were male. The mean age of the participants was 39.16
±7 years (16 to 75), and the mean follow-up was 48±3 months. All of the subjects underwent IV Procainamide and oral Flecainide challenge test. Among these patients 19 patients had positive results.
Results: Nineteen patients had positive responses (15%); 18 of them were male (94.7%) and one of them was female. These 19 patients all had a positive Procainamide challenge test. Only 9 of these patients had a positive Flecainide test. In the diagnosed Brugada Syndrome patients, IV Procainamide had a 100% positive response rate in comparison to a 47.4% positive rate in oral Flecainide.
Conclusions: Different Brugada challenge tests have different sensitivities in the diagnosis of BS. IV procainamide is more sensitive than oral Flecainide and the latter cannot be used solely to rule out BS.
 
Keyword(s): BRUGADA SYNDROME, FLECAINIDE CHALLENGE TEST, IV PROCAINAMIDE CHALLENGE TEST
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HASHEMI, A., & SHAHRZAD, S., & SHAHRZAD, S., & HASHEMI, M., & SABER, S., & TABAN, S., & HASHEMI, A., & ASLANI, A., & EMKANJOO, Z. (2012). ORAL FLECAINIDE IS NOT SENSITIVE ENOUGH TO RULE OUT BRUGADA-SYNDROME. IRANIAN HEART JOURNAL (IHJ), 13(1), 34-39. https://www.sid.ir/en/journal/ViewPaper.aspx?id=275592



Vancouver: Copy

HASHEMI ARASH, SHAHRZAD SHAHAB, SHAHRZAD SORAYA, HASHEMI M.J., SABER SIAMAK, TABAN SAMIRA, HASHEMI ASHKAN, ASLANI AMIR, EMKANJOO ZAHRA. ORAL FLECAINIDE IS NOT SENSITIVE ENOUGH TO RULE OUT BRUGADA-SYNDROME. IRANIAN HEART JOURNAL (IHJ). 2012 [cited 2021August02];13(1):34-39. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275592



IEEE: Copy

HASHEMI, A., SHAHRZAD, S., SHAHRZAD, S., HASHEMI, M., SABER, S., TABAN, S., HASHEMI, A., ASLANI, A., EMKANJOO, Z., 2012. ORAL FLECAINIDE IS NOT SENSITIVE ENOUGH TO RULE OUT BRUGADA-SYNDROME. IRANIAN HEART JOURNAL (IHJ), [online] 13(1), pp.34-39. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275592.



 
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