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Paper Information

Journal:   GOVARESH JOURNAL   WINTER 2010 , Volume 14 , Number 4 (69); Page(s) 211 To 218.
 
Paper: 

ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L. (SAFFRON) STIGMA AGAINST RIFAMPIN INDUCED HEPATOTOXICITY

 
 
Author(s):  MOHAJERI D.*, DOUSTAR Y., RAHMANI J.
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, ISLAMIC AZAD UNIVERSITY, TABRIZ BRANCH, IRAN
 
Abstract: 

Background: Tuberculosis continues to be a common health problem worldwide. Rifampin, an antibiotic used routinely for tuberculosis chemotherapy is documented to be a potent hepatotoxicant. The aim of the present study was to assess the antioxidant activity of ethanolic extract of Crocus sativus L. stigma (EECSL.S) against rifampin induced hepatotoxicity in the rats.
Materials and Methods: Male Wistar rats were randomly assigned into 5 groups of 8 animals each. Group I served as normal control and received normal saline (10 ml/kg). Group II served as toxicant control and received rifampin (500 mg/kg). The reference drug silymarin (50 mg/kg), EECSL.S at 40 mg/kg and EECSL.S at 80 mg/kg were administered to the groups III-V, respectively. These three groups received rifampin (500 mg/kg) too. All treatments were administered by P.O. route dissolving in 10 ml/kg normal saline daily for 1 month. At the end of experiment, product of lipid peroxidation (MDA), activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GR) were assayed in liver homogenates to evaluate antioxidant activity. Significant differences among the groups were determined by one way analysis of variance followed by Bonferroni post-test. Statistical significance was considered at p<0.05.
Results: In rifampin-treated rats, EECSL.S (40 and 80 mg/kg) and silymarin significantly decreased the lipid peroxidation and elevated the levels of antioxidant enzymes, in a dose dependent manner.
Conclusion: The present findings suggest that the hepatoprotective effect of Crocus sativus L. stigma in rifampin induced oxidative damage may be related to its antioxidant and free radical scavenging activity.

 
Keyword(s): CROCUS SATIVUS L, RIFAMPIN, HEPATOTOXICITY, ANTIOXIDANT, RAT
 
 
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Citations: 
 
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APA: Copy

MOHAJERI, D., & DOUSTAR, Y., & RAHMANI, J. (2010). ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L. (SAFFRON) STIGMA AGAINST RIFAMPIN INDUCED HEPATOTOXICITY. GOVARESH JOURNAL, 14(4 (69)), 211-218. https://www.sid.ir/en/journal/ViewPaper.aspx?id=275058



Vancouver: Copy

MOHAJERI D., DOUSTAR Y., RAHMANI J.. ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L. (SAFFRON) STIGMA AGAINST RIFAMPIN INDUCED HEPATOTOXICITY. GOVARESH JOURNAL. 2010 [cited 2021July30];14(4 (69)):211-218. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275058



IEEE: Copy

MOHAJERI, D., DOUSTAR, Y., RAHMANI, J., 2010. ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L. (SAFFRON) STIGMA AGAINST RIFAMPIN INDUCED HEPATOTOXICITY. GOVARESH JOURNAL, [online] 14(4 (69)), pp.211-218. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=275058.



 
 
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