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Paper Information

Journal:   IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE   OCTOBER 2009 , Volume 14 , Number 46; Page(s) 11 To 14.
 
Paper: 

ASSOCIATION OF POLYMORPHISM OF HLA-DRBI *13 AND HLA-A *33 ALLELES WITH OUTCOME OF HEPATITIS B VIRUS INFECTION

 
 
Author(s):  VELAYATI A.A., AGHAKHANI A., BANIFAZL M., KALANTAR E., ESLAMIFAR A., KHADEMI Z., RAMEZANI A.*
 
* 
 
Abstract: 
Background and objective: The outcome of hepatitis B infection may be influenced by host factors like Human Leukocyte Antigen (HLA). We have investigated HLA-A and DRBI alleles in patients with persistent hepatitis B infection compared to subjects who had spontaneously recovered from HBV infection. To complete the findings of this study we performed another survey to determine predominant subtypes of HLA-A*33 and HLA-DRBI *13 alleles were associated with HBV infection outcomes.
Materials and methods: Ninety-four HBV infected patients were enrolled in the study. First HLA-A and DRBI alleles were analyzed by using low resolution PCR sequence-specific-primer (PCR-SSP) and then we used high resolution PCR-SSP method for sub typing HLA-A*33 and DRBI *13 alleles were significantly related to the outcome of HBV infection.
Results: HLA-A*33 allele was significantly higher in persistent group than recovered group and sub typing showed HLA-A*3303 in 75% and HLA-A*330l in 25% of cases. HLA-DRBI *13 allele was significantly lower in persistent group than in recovered group and their subtypes were DRBI *1301 in 66.7% and DRBI *1303 in 33.3% of subjects.
Conclusion: HLA-A*3303 and DRBI *1301 were the predominant HLA subtypes related to outcome of HBV infection. These findings emphasized that HLA is an important factor to determining the outcome of HBV infection.
 
Keyword(s): HEPATITIS B, HUMAN LEUKOCYTE ANTIGEN (HLA), HIGH RESOLUTION PCR-SSP
 
References: 
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