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Paper Information

Journal:   IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE   MARCH 2010 , Volume 15 , Number 48; Page(s) 13 To 17.
 
Paper: 

HUMAN PAPILLOMAVIRUS INFECTION IN PROSTATE CARCINOMA

 
 
Author(s):  HAMKAR R., PARVIN M., GHAVAMI N., RAMEZANI A., NADRI M., BANIFAZL M., PAKFETRAT A., ESLAMIFAR A., AGHAKHANI A.*
 
* 
 
Abstract: 
Background and objective: Human papillomavirus (HPV) infections are frequently associated with benign and malignant lesions of the female genital region and male ano-genital tract. Currently the possible role of HPV infections in prostate carcinoma is a subject of great controversy. In this study we aimed to investigate the involvement of HPV infection in prostate carcinoma (PCa).
Materials and methods: The study included formalin-fixed paraffin-embedded tissue samples of 104 primary prostate adenocarcinoma cases and 104 control tissues of benign prostatic hyperplasia (BPH). HPV-DNA was purified and amplified through nested PCR and subsequently subjected to sequencing.
Results: HPV-DNA was found in 13 of 104 (12.5%) PCa and 8 of 104 (7.7%) BPH samples.
There was not any significant difference between PCa and BPH specimens regarding HPV-DNA presence. High-risk HPVs were detected in 10 of 13 (76.9%) PCa and 5 of 8 (62.5%) BPH samples with positive HPV-DNA. Low-risk HPVs were detected in 3 of 13 (23.1%) PCa and 3 of 8 (37.5%) BPH specimens with positive HPV-DNA. There was not any significant difference between PCa and BPH specimens regarding the presence of high-risk and low-risk HPVs.
Conclusion: Our data do not support the involvement of HPV infection in prostate carcinoma.
Furth. are studi.es are required to elucidate the involvement of HPV infection in human prostate Carcinoma.
 
Keyword(s): HUMAN PAPILLOMAVIRUS (HPV), PROSTATE CARCINOMA (PCA), BENIGN PROSTATIC HYPERPLASIA (BPH)
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HAMKAR, R., & PARVIN, M., & GHAVAMI, N., & RAMEZANI, A., & NADRI, M., & BANIFAZL, M., & PAKFETRAT, A., & ESLAMIFAR, A., & AGHAKHANI, A. (2010). HUMAN PAPILLOMAVIRUS INFECTION IN PROSTATE CARCINOMA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 15(48), 13-17. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274916



Vancouver: Copy

HAMKAR R., PARVIN M., GHAVAMI N., RAMEZANI A., NADRI M., BANIFAZL M., PAKFETRAT A., ESLAMIFAR A., AGHAKHANI A.. HUMAN PAPILLOMAVIRUS INFECTION IN PROSTATE CARCINOMA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE. 2010 [cited 2021September17];15(48):13-17. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274916



IEEE: Copy

HAMKAR, R., PARVIN, M., GHAVAMI, N., RAMEZANI, A., NADRI, M., BANIFAZL, M., PAKFETRAT, A., ESLAMIFAR, A., AGHAKHANI, A., 2010. HUMAN PAPILLOMAVIRUS INFECTION IN PROSTATE CARCINOMA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, [online] 15(48), pp.13-17. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274916.



 
 
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