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Paper Information

Journal:   IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE   MARCH 2010 , Volume 15 , Number 48; Page(s) 13 To 17.
 
Paper: 

HUMAN PAPILLOMAVIRUS INFECTION IN PROSTATE CARCINOMA

 
 
Author(s):  HAMKAR R., PARVIN M., GHAVAMI N., RAMEZANI A., NADRI M., BANIFAZL M., PAKFETRAT A., ESLAMIFAR A., AGHAKHANI A.*
 
* 
 
Abstract: 
Background and objective: Human papillomavirus (HPV) infections are frequently associated with benign and malignant lesions of the female genital region and male ano-genital tract. Currently the possible role of HPV infections in prostate carcinoma is a subject of great controversy. In this study we aimed to investigate the involvement of HPV infection in prostate carcinoma (PCa).
Materials and methods: The study included formalin-fixed paraffin-embedded tissue samples of 104 primary prostate adenocarcinoma cases and 104 control tissues of benign prostatic hyperplasia (BPH). HPV-DNA was purified and amplified through nested PCR and subsequently subjected to sequencing.
Results: HPV-DNA was found in 13 of 104 (12.5%) PCa and 8 of 104 (7.7%) BPH samples.
There was not any significant difference between PCa and BPH specimens regarding HPV-DNA presence. High-risk HPVs were detected in 10 of 13 (76.9%) PCa and 5 of 8 (62.5%) BPH samples with positive HPV-DNA. Low-risk HPVs were detected in 3 of 13 (23.1%) PCa and 3 of 8 (37.5%) BPH specimens with positive HPV-DNA. There was not any significant difference between PCa and BPH specimens regarding the presence of high-risk and low-risk HPVs.
Conclusion: Our data do not support the involvement of HPV infection in prostate carcinoma.
Furth. are studi.es are required to elucidate the involvement of HPV infection in human prostate Carcinoma.
 
Keyword(s): HUMAN PAPILLOMAVIRUS (HPV), PROSTATE CARCINOMA (PCA), BENIGN PROSTATIC HYPERPLASIA (BPH)
 
References: 
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