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Paper Information

Journal:   IRANIAN SOUTH MEDICAL JOURNAL (ISMJ)   WINTER 2013 , Volume 15 , Number 4; Page(s) 263 To 274.
 
Paper: 

EFFECT OF TESTOSTERONE ON PANCREATIC BETA CELLS RESISTANCE AND BLOOD GLUCOSE CONTROL IN DIABETIC MALE RATS BY STREPTOZOTOCIN

 
 
Author(s):  MANSOORPOOR S., AZIZI Z., ASAIE S., RANJBAR OMRANI GH.*
 
* ENDOCRINOLOGY AND METABOLISM RESEARCH CENTER, SCHOOL OF MEDICINE, SHIRAZ UNIVERSITY OF MEDICAL SCEINECS, FARS, IRAN
 
Abstract: 

Background: Diabetes mellitus (DM) is the most common carbohydrate metabolic disorder, with defective insulin secretory or insulin receptor function, or both. We examined the protective effect of testosterone against the destruction of pancreatic b-cells by streptozotocin (STZ).
Material and Methods: This empirical cross-sectional research involved 56 adult male rats (mean wt 220 g) randomized to: group 1, food and water, group 2, olive oil injection, group 3, STZ-induced DM, group 4, castrated rats, group 5, gonadectomy+STZ, group 6, gonadal hormone+STZ, group 7, gonadal hormone+ STZ+gonadal hormone. Testosterone enanthate was injected intramuscularly (50 mg/kg in group 6, 4 weeks before DM induction, and 50 mg/kg in group 7, 4 weeks before and 2 weeks after DM). Diabetes was induced by 60 mg/kg, intraperitoneal STZ (STZ, 20130 Sigma-Aldrich) in citrate buffer. Data were analyzed using SPSS16 software.
Results: In groups 6 and 7 (testosterone) blood glucose was significantly lower than in groups 3 and 5 (P≤0.001). Groups 6 and 7 also had higher serum insulin concentrations (P≤0.05) and absolute numbers of islet cells compared to other groups (P≤0.001).
Conclusion: Testosterone exerted a protective effect against early STZ-induced apoptotic damage to pancreatic b-cells.

 
Keyword(s): TESTOSTERONE, PANCREAS, STREPTOZOTOCIN, STEREOLOGY
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

MANSOORPOOR, S., & AZIZI, Z., & ASAIE, S., & RANJBAR OMRANI, G. (2013). EFFECT OF TESTOSTERONE ON PANCREATIC BETA CELLS RESISTANCE AND BLOOD GLUCOSE CONTROL IN DIABETIC MALE RATS BY STREPTOZOTOCIN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), 15(4), 263-274. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274905



Vancouver: Copy

MANSOORPOOR S., AZIZI Z., ASAIE S., RANJBAR OMRANI GH.. EFFECT OF TESTOSTERONE ON PANCREATIC BETA CELLS RESISTANCE AND BLOOD GLUCOSE CONTROL IN DIABETIC MALE RATS BY STREPTOZOTOCIN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ). 2013 [cited 2021July28];15(4):263-274. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274905



IEEE: Copy

MANSOORPOOR, S., AZIZI, Z., ASAIE, S., RANJBAR OMRANI, G., 2013. EFFECT OF TESTOSTERONE ON PANCREATIC BETA CELLS RESISTANCE AND BLOOD GLUCOSE CONTROL IN DIABETIC MALE RATS BY STREPTOZOTOCIN. IRANIAN SOUTH MEDICAL JOURNAL (ISMJ), [online] 15(4), pp.263-274. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274905.



 
 
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