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Paper Information

Journal:   IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE   JANUARY 2010 , Volume 14 , Number 47; Page(s) 39 To 42.
 
Paper: 

PERSISTENCE OF ANTI-HBS ANTIBODY IN HBV VACCINATED CHILDREN IN A LOW ENDEMIC AREA FOR HBV

 
 
Author(s):  IZADI N., AGHAKHANI A., BANIFAZL M., SOFIAN M., MAHDAVIANI F.S., ESLAMIFAR A., KHADEM SADEGH A., RAMEZANI A.*
 
* 
 
Abstract: 
Background and objective: hepatitis B virus (RBV) infection is one of the most widespread infections in the world A potential problem of hepatitis B immunization is that hepatitis B surface antibody (anti-HBs) titers decline with age. The present study was designed to investigate the persistence of anti-RBs levels in vaccinated children in a low endemic area.
Materials and methods: Plasma samples of 938 children between ages of 8 months and 15 years were tested for the presence of anti-RBs.
Results: The overall seroprotection rate was 59.6% in vaccinated children. Protective antibody levels can be detected in 65% of one year vaccinees, 30% in 5 years after vaccination, 29% and 24% in 10 and 15 years after vaccination. The mean anti-RBs declined with post-vaccination time (65.66
±38.41 mIU/ml in 1 year vaccinees, 59.88±44.37 in 5, 40.37±40.77 in 10 and 37.31±42.91 in 15 years post vaccination). Seroprotection rates decreased significantly with increasing age, due to waning anti-RBs titer over time.
Conclusion: Children vaccinated against hepatitis B during infancy may show low levels of antibody during adolescence.
Because the issue of booster dosing is still debatable, our data suggest that a booster dose of vaccine may be required in areas where endemicity is low.
 
Keyword(s): HBV, ANTI-HBS, LOW ENDEMIC AREA
 
References: 
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