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Paper Information

Journal:   IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE   JULY 2010 , Volume 15 , Number 49; Page(s) 37 To 41.
 
Paper: 

IMIPENEM AND METALLO- β -IACTAMASES ENZYMES RESISTANCE IN β LACTAMASE PRODUCING CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA

 
 
Author(s):  NOROUZI F., KALANTAR D., MANSOURI S.*, MORADI M., VALIPOUR E., ORANGI M.
 
* 
 
Abstract: 

Background and Objectives: Imipenem use as therapeutic for infections associated with drug resistant gram negative bacteria harboring ESBL and Amp C genes. Resistance to imipenem cause with emerged metallo-b-lactamases.
Considering to the importance role of Pseudomonas aeruginosa in nosocomial infection, the aim of the study was to determine the imipenem resistance and presence of metallo-
b-lactamases (MBLs) in b-lactamase producing clinical isolates of P.aeruginosa.
Materials and methods: sixty P.aeruginosa species isolate from bum patient in Ghotbodin hospital of Shiraz. Resistance to cefotaxime, ceftazidime and imipenem was determined by disk diffusion method. Disk diffusion method was used for determination presence of metallo-
b- lactamases. The Disks containing 10Ilg imipenem and 10llg imipenem+10 ml EDTA 0.5 M were used. The increase of inhibition zone ³7mm of imipenem tested in combination with EDTA versus imipenem alone was considered positive for MBL. Resistances to seven different antibiotics were determined.
Results: From total of 60
b -lactamase producing isolates of P.aeruginosa, 18 isolates were found to be resistant to Imipenem, that five isolates were determined to be MBL producers by phenotypic method. All producing MBLs isolates were resistance more than to eight antibiotics from different classes simultaneously.
Conclusion: According to the presence of metallo
b lactamases in bacterial strain in the region, also increasing use carbapenems in treatment of infections by producing MBLs and multi drug resistance isolates in our country is not unexpected.

 
Keyword(s): IMIPENEM, METALLO-β-IACTAMASES, P.AERUGINOSA
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

NOROUZI, F., & KALANTAR, D., & MANSOURI, S., & MORADI, M., & VALIPOUR, E., & ORANGI, M. (2010). IMIPENEM AND METALLO- β -IACTAMASES ENZYMES RESISTANCE IN β LACTAMASE PRODUCING CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, 15(49), 37-41. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274837



Vancouver: Copy

NOROUZI F., KALANTAR D., MANSOURI S., MORADI M., VALIPOUR E., ORANGI M.. IMIPENEM AND METALLO- β -IACTAMASES ENZYMES RESISTANCE IN β LACTAMASE PRODUCING CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE. 2010 [cited 2021July24];15(49):37-41. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274837



IEEE: Copy

NOROUZI, F., KALANTAR, D., MANSOURI, S., MORADI, M., VALIPOUR, E., ORANGI, M., 2010. IMIPENEM AND METALLO- β -IACTAMASES ENZYMES RESISTANCE IN β LACTAMASE PRODUCING CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. IRANIAN JOURNAL OF INFECTIOUS DISEASES AND TROPICAL MEDICINE, [online] 15(49), pp.37-41. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274837.



 
 
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