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Paper Information

Journal:   VETERINARY RESEARCH FORUM   2012 , Volume 3 , Number 2; Page(s) 147 To 149.
 
Paper: 

PROTEIN 53 EXPRESSION IN A MIXED LABRADOR SUBCUTANEOUS LYMPHOMA

 
 
Author(s):  REZAIE ANNAHITA*, TAVASSOLI ABBAS
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, SHAHID CHAMRAN UNIVERSITY OF AHVAZ, AHVAZ, IRAN
 
Abstract: 

An 11 year - old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than 10% lymphoid cells were CD3 positive in the immunohistochemical staining and most of them were accumulated around vessels. Protein 53 (p53) expression was detected by brown nuclei in immunohistochemical staining. Subcutaneous lymphoma was diagnosed according to histopathological results. After 6 months the case was referred with multicentric lymphoma and based on the owner request euthanasia was performed. These findings emphasize on poor prognosis for tumors with p53 mutation.

 
Keyword(s): SUBCUTANEOUS LYMPHOMA, DOG, P53, T CELL, IMMUNOHISTOCHEMISTRY
 
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