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Paper Information

Journal:   MODERN GENETICS JOURNAL (MGJ)   SPRING 2007 , Volume 2 , Number 1; Page(s) 55 To 63.
 
Paper: 

EXPRESSION REDUCTION OF GROWTH FACTOR TYPE I LIKE INSULINE IN HUMAN PROSTATE CANCER CELLS DU-145

 
 
Author(s):  JALAL R., ANSARI MAJD S., ROKNIZADEH R., DARVISH ALIPOUR ASTANEH SH.
 
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Abstract: 

Prostate cancer has been known as the second leading cause of death in men. Different methods are employed in prostate cancer treatment, including surgery, radiotherapy, hormone therapy, and chemotherapy. The application of each of these treatments depends upon the clinical stage but none of them increase survival effectively. Gene therapy is suggested as a valuable method in cancers including prostate cancer.
Insulin-like growth factors (IGFs) are known as strong mitogens. Recent studies have shown that IGFs particularly the type I insulin-like growth factor (IGF-IR) play an important role in the regulation of tumor growth. Inhibition of IGF-IR signaling by using antibody or antisense against IGF-IR could inhibit the growth and plating efficiency of some cancer cells in vivo and in vitro. It has been demonstrated that some of the human prostate cancer cell lines, especially DU-145, overexpress IGF-IR. In the present study, we have used the antisense strategy to reduce the IGF-IR expression in DU-145 cells. For this purpose, DU-145 cells were transfected with the antisense IGF-IR expression vector and the level of IGF-IR mRNA and protein was measured by using RTPCR and immunoblotting. The RT-PCR and immunoblotting results show the significant reduction in mRNA and protein of IGF-IR as compared with DU-145 transfected cells with control vector and untransfected DU-145 cells.

 
Keyword(s): IGF, PROSTATE CANCER, ANTISENCE TECHNOLOGY
 
 
References: 
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Click to Cite.
APA: Copy

JALAL, R., & ANSARI MAJD, S., & ROKNIZADEH, R., & DARVISH ALIPOUR ASTANEH, S. (2007). EXPRESSION REDUCTION OF GROWTH FACTOR TYPE I LIKE INSULINE IN HUMAN PROSTATE CANCER CELLS DU-145. MODERN GENETICS JOURNAL (MGJ), 2(1), 55-63. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274616



Vancouver: Copy

JALAL R., ANSARI MAJD S., ROKNIZADEH R., DARVISH ALIPOUR ASTANEH SH.. EXPRESSION REDUCTION OF GROWTH FACTOR TYPE I LIKE INSULINE IN HUMAN PROSTATE CANCER CELLS DU-145. MODERN GENETICS JOURNAL (MGJ). 2007 [cited 2021May14];2(1):55-63. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274616



IEEE: Copy

JALAL, R., ANSARI MAJD, S., ROKNIZADEH, R., DARVISH ALIPOUR ASTANEH, S., 2007. EXPRESSION REDUCTION OF GROWTH FACTOR TYPE I LIKE INSULINE IN HUMAN PROSTATE CANCER CELLS DU-145. MODERN GENETICS JOURNAL (MGJ), [online] 2(1), pp.55-63. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274616.



 
 
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