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Paper Information

Journal:   VETERINARY RESEARCH FORUM   2012 , Volume 3 , Number 2; Page(s) 125 To 130.
 
Paper: 

BLOOD OXYGENATION DURING HYPERPRESSURE INTRAPERITONEAL FLUID ADMINISTRATION IN A RABBIT MODEL OF SEVERE LIVER INJURY: EVALUATION OF A NOVEL CONCEPT FOR CONTROL OF PRE-HOSPITAL LIVER BLEEDING

 
 
Author(s):  AHMADI NOORBAKHSH SIAVASH, AZIZI SAEED*, DALIR NAGHADEH BAHRAM, MAHAM MASOUD
 
* DEPARTMENT OF CLINICAL SCIENCES, FACULTY OF VETERINARY MEDICINE, URMIA UNIVERSITY, URMIA, IRAN
 
Abstract: 

Oxygen is an essential part of the most important metabolic pathways in aerobic organisms. Oxygen delivery is merely dependent on blood, rendering blood loss a devastating event. Traumatic pre-hospital liver bleeding is a major cause of early trauma deaths in human and animals, with no established therapeutic method yet. Increasing intra-abdominal pressure (IAP) has been shown to reduce liver bleeding by half. Although reduction of blood loss could be in favor of blood oxygen delivery, however, the complex interaction between increased IAP and respiratory mechanics during severe hemorrhagic shock remained unclear. We used a novel model of liver trauma in 16 rabbits and randomly assigned them to either normotensive abdomen group or increased IAP by fluid infusion (HA) groups (n=8 each). Liver size and the amount of liver injury were evaluated. Various blood oxygenation parameters were recorded. Both groups were identical in terms of the liver size and injury. The HA group had significantly lower shock index. Arterial oxygen capacity and oxygen content were higher in the HA group. No significant statistical difference was seen between groups in terms of abdominal perfusion pressure; alveolar pressure of oxygen; dissolved oxygen in blood plasma; alveolar to arterial oxygen tension gradient; arterial to alveolar oxygen pressure ratio; the ratio between partial pressure of arterial oxygen and fraction of inspired oxygen; and respiratory index. In conclusion, the novel therapeutic method of increasing IAP by fluid infusion in a rabbit model of liver hemorrhage preserved blood oxygenation better than the classic therapeutic method.

 
Keyword(s): INTRA-ABDOMINAL HYPERTENSION, LIVER, HEMORRHAGE, PRE-HOSPITAL CARE, RABBIT
 
 
References: 
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Citations: 
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APA: Copy

AHMADI NOORBAKHSH, S., & AZIZI, S., & DALIR NAGHADEH, B., & MAHAM, M. (2012). BLOOD OXYGENATION DURING HYPERPRESSURE INTRAPERITONEAL FLUID ADMINISTRATION IN A RABBIT MODEL OF SEVERE LIVER INJURY: EVALUATION OF A NOVEL CONCEPT FOR CONTROL OF PRE-HOSPITAL LIVER BLEEDING. VETERINARY RESEARCH FORUM, 3(2), 125-130. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274566



Vancouver: Copy

AHMADI NOORBAKHSH SIAVASH, AZIZI SAEED, DALIR NAGHADEH BAHRAM, MAHAM MASOUD. BLOOD OXYGENATION DURING HYPERPRESSURE INTRAPERITONEAL FLUID ADMINISTRATION IN A RABBIT MODEL OF SEVERE LIVER INJURY: EVALUATION OF A NOVEL CONCEPT FOR CONTROL OF PRE-HOSPITAL LIVER BLEEDING. VETERINARY RESEARCH FORUM. 2012 [cited 2021July28];3(2):125-130. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274566



IEEE: Copy

AHMADI NOORBAKHSH, S., AZIZI, S., DALIR NAGHADEH, B., MAHAM, M., 2012. BLOOD OXYGENATION DURING HYPERPRESSURE INTRAPERITONEAL FLUID ADMINISTRATION IN A RABBIT MODEL OF SEVERE LIVER INJURY: EVALUATION OF A NOVEL CONCEPT FOR CONTROL OF PRE-HOSPITAL LIVER BLEEDING. VETERINARY RESEARCH FORUM, [online] 3(2), pp.125-130. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274566.



 
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