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Paper Information

Journal:   ADVANCES IN COGNITIVE SCIENCE   WINTER 2008 , Volume 9 , Number 4 (36); Page(s) 1 To 8.
 
Paper: 

ROLE OF L-ARGININE/NITRIC OXIDE PATHWAY IN THE ANTIDEPRESSANT-LIKE EFFECTS OF ACUTE LITHIUM ADMINISTRATION IN THE MOUSE FORCED SWIMMING TEST

 
 
Author(s):  GHASEMI MEHDI, SADEGHIPOUR ROUDSARI HAMED, DEHPOUR AHMAD REZA, SADEGHIPOUR ROUDSARI HAMID REZA
 
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Abstract: 
Objective: In the present study we evaluated the involvement of L-arginine/nitric oxide (NO) pathway in the antidepressant-like effects of acute lithium administration in the mouse forced swimming test (FST).
Methods: It was an experimental study. Forced swimming test was applied as a model for depression; the immobility time was considered as an indicator of depression. In the present study, the effects of lithium (0.5-100 mg/kg), the nonselective NO synthase (NOS) inhibitor, NpGP -nitro-L-arginine methyl ester (L-NAME, 10-100 mg/kg), the specific neuronal NOS inhibitor, NpwP-propyl-L-arginine (L-NPA, 5-15 mg/kg), and the NO precursor L-arginine (750 mg/kg) were evaluated.
Results: Lithium, at 30 and 100 mg/kg, significantly reduced the immobility times of mice in the FST, whereas at lower doses (0.5, 5 and 10 mg/kg) had no effect on the immobility time. L-NAME, at 10 and 30 mg/kg, and LNPA, at 5 and 15 mg/kg, had no significant effects on the FST, whereas they significantly decreased the immobility time at 100 and 30 mg/kg, respectively. Combination of non effective dose of lithium (10 mg/kg) with low doses of L-NAME (30 mg/kg) or L-NPA (15 mg/kg) significantly reduced the immobility time in the FST. Non-effective dose of L-arginine (750 mg/kg) significantly reversed the antidepressant-like effect of 30 mg/kg lithium in the FST.
Conclusion: These data indicate the involvement of L-arginine/NO pathway in the antidepressant-like effect of lithium in the mouse FST and also might suggest the concurrent administration of NOS inhibitors and lithium as an appropriate strategy for treatment of depression.
 
Keyword(s): LITHIUM, DEPRESSION NITRIC OXIDE, NOS INHIBITOR, FORCED SWIMMING TEST
 
References: 
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