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Paper Information

Journal:   JOURNAL OF NORTH KHORASAN UNIVERSITY OF MEDICAL SCIENCES   SPRING 2012 , Volume 4 , Number 1 (11); Page(s) 105 To 111.
 
Paper: 

EVALUATION OF ANALGESIC EFFECT OF GLUCOSE - INSULIN - POTASSIUM IN ACUTE MYOCARDIAL INFARCTION

 
DOI: 

10.29252/jnkums.4.1.105

 
Author(s):  HASHEMIAN M., VAKILI A.R., AKABERI A.*
 
* NORH KHORASAN UNIVERSITY OF MEDICAL SCIENCES
 
Abstract: 

Background & Objectives: chest pain control is one of the most important components of guidelines for acute myocardial infarction. An analgesic effect of glucose, insulin potassium solution has been suggested in a few studies. Hence this study was performed to evaluate the effect of this solution on the intensity of chest pain in patients with myocardial infarction.
Materials & Methods: This randomized clinical trial enrolled 72 patients who had myocardial infarction that was treated with 25% glucose, 50 unit of soluble insulin per liter, and 80 mille mol of potassium chloride per liter at 1 ml/kg/hour (case group) or normal saline (control group) as adjunct to thrombolytic therapy. We evaluated pain intensity at baseline, after receiving thrombolytic therapy and 1 hour later, in both groups by a Numeric Rating Scale. Statistical analysis was performed using SPSS 15. Variables were compared using independent t tests and repeated measure ANOVA or chi-square test.
Results: In both groups pain intensity after receiving streptokinase and an hour later dropped, but there was no significant differences between two groups (P=0.121). Difference between intravenous drug consumption in the two groups was not significant (P=0.93).
Conclusion: The administration of potassium, glucose, insulin has no effect on chest pain in patients with myocardial infarction.

 
Keyword(s): GLUCOSE, INSULIN, POTASSIUM, MYOCARDIAL INFARCTION, PAIN, GIK
 
References: 
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