Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   FALL 2012 , Volume 14 , Number 3 (55); Page(s) 231 To 236.
 
Paper: 

THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA

 
 
Author(s):  SOLEIMANI MANSOOREH, KATEBI MAJID, ALIZADEH AKRAM, MOHAMMADZADEH FARZANEH, MEHDIZADEH MEHDI*
 
* DEPARTMENT OF ANATOMY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Objective: Ecstasy, also known as 3, 4-methylenedioxymethamphetamine (MDMA), is a psychoactive recreational hallucinogenic substance and a major worldwide recreational drug.
There are neurotoxic effects observed in laboratory animals and humans following MDMA use. MDMA causes apoptosis in neurons of the central nervous system (CNS). Withdrawal signs are attenuated by treatment with the adenosine receptor (A2A receptor). This study reports the effects of glutamyl cysteine synthetase (GCS), as an A2A receptor agonist, and succinylcholine (SCH), as an A2A receptor antagonist, on Sprague Dawley rats, both in the presence and absence of MDMA.
Materials and Methods: In this experimental study, we used seven groups of Sprague Dawley rats (200-250 g each). Each group was treated with daily intraperitoneal (IP) injections for a period of one week, as follows: i. MDMA (10 mg/kg); ii.
GCS (0.3 mg/kg); iii. SCH (0.3 mg/kg); iv. GCS+SCH (0.3 mg/kg each); v. MDMA (10 mg/kg) +GCS (0.3 mg/kg); vi. MDMA (10 mg/kg) +SCH (0.3 mg/kg); and vi.
normal saline (1 cc/kg) as the sham group. Bax (apoptotic protein) and Bcl-2 (anti-apoptotic protein) expressions were evaluated by striatum using RT-PCR and Western blot analysis.
Results: There was a significant increase in Bax protein expression in the MDMA+SCH group and a significant decrease in Bcl-2 protein expression in the MDMA+SCH group (p<0.05).
Conclusion: A2A receptors have a role in the apoptotic effects of MDMA via the Bax and Bcl-2 pathways. An agonist of this receptor (GCS) decreases the cytotoxcity of MDMA, while the antagonist of this receptor (SCH) increases its cytotoxcity.

 
Keyword(s): ECSTASY OR MDMA, NEUROTOXICITY, ADENOSINE RECEPTOR, AGONIST OF A2A RECEPTOR, ANTAGONIST OF A2A RECEPTOR
 
 
References: 
  • ندارد
  •  
 
Click to Cite.
APA: Copy

SOLEIMANI, M., & KATEBI, M., & ALIZADEH, A., & MOHAMMADZADEH, F., & MEHDIZADEH, M. (2012). THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA. CELL JOURNAL (YAKHTEH), 14(3 (55)), 231-236. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274418



Vancouver: Copy

SOLEIMANI MANSOOREH, KATEBI MAJID, ALIZADEH AKRAM, MOHAMMADZADEH FARZANEH, MEHDIZADEH MEHDI. THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA. CELL JOURNAL (YAKHTEH). 2012 [cited 2021May08];14(3 (55)):231-236. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274418



IEEE: Copy

SOLEIMANI, M., KATEBI, M., ALIZADEH, A., MOHAMMADZADEH, F., MEHDIZADEH, M., 2012. THE ROLE OF THE A2A RECEPTOR IN CELL APOPTOSIS CAUSED BY MDMA. CELL JOURNAL (YAKHTEH), [online] 14(3 (55)), pp.231-236. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274418.



 
  pdf-File
Yearly Visit 60
 
Latest on Blog
Enter SID Blog