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Paper Information

Journal:   JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2012 , Volume 20 , Number 2; Page(s) 17 To 22.
 
Paper: 

EFFECT OF OPIUM ADDICTION ON T4, T3 AND TSH IN MALE AND FEMALE RATS

 
 
Author(s):  MAMI S.*, EGHBALI M., KHOSRAVI A., SALATI A.P., PURMEHDI BROJENI M.*, MAMI F., HUSHMANDFAR R.*
 
* DEPT OF VETERINARY MEDICINE, ILAM UNIVERSITY, ILAM, IRAN
 
Abstract: 

Introduction: Opium addiction is a serious social problem in Iran. Beside the social effects, opium addiction has various physiologic consequences. Thyroid hormones have a direct effect on metabolism and at present study the effects of opium addiction on thyroid stimulating hormone (TSH), triiodothyronine (T3) and thyroxin (T4) was evaluated.
Materials & Methods: 60 rats (30 male and 30 female weighting 250-300 g) were randomly divided into control and addicted groups. Addicted groups received opium solution in gavage for 60 days, by the end of the study, blood samples were taken from all groups and T4, T3 and TSH of addicted group were compared with control groups.
Findings: In male and female addicted rats T4 decreased and TSH increased but T3 did not alter significantly.
Discussion & Conclusion: It can be concluded that addication to opium can cause an increase in TSH hormone and a decrease in T4 but no effect on T3. It can also be claimed that opium addiction can affect on the thyroid gland function.

 
Keyword(s): ADDICTION, OPIUM, THYROID HORMONE, RAT
 
 
References: 
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Citations: 
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APA: Copy

MAMI, S., & EGHBALI, M., & KHOSRAVI, A., & SALATI, A., & PURMEHDI BROJENI, M., & MAMI, F., & HUSHMANDFAR, R. (2012). EFFECT OF OPIUM ADDICTION ON T4, T3 AND TSH IN MALE AND FEMALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 20(2), 17-22. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274373



Vancouver: Copy

MAMI S., EGHBALI M., KHOSRAVI A., SALATI A.P., PURMEHDI BROJENI M., MAMI F., HUSHMANDFAR R.. EFFECT OF OPIUM ADDICTION ON T4, T3 AND TSH IN MALE AND FEMALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES. 2012 [cited 2021May18];20(2):17-22. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274373



IEEE: Copy

MAMI, S., EGHBALI, M., KHOSRAVI, A., SALATI, A., PURMEHDI BROJENI, M., MAMI, F., HUSHMANDFAR, R., 2012. EFFECT OF OPIUM ADDICTION ON T4, T3 AND TSH IN MALE AND FEMALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, [online] 20(2), pp.17-22. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274373.



 
 
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