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Paper Information

Journal:   CELL JOURNAL (YAKHTEH)   FALL 2012 , Volume 14 , Number 3 (55); Page(s) 177 To 184.
 
Paper: 

ZINGIBER OFFICINALE ALTERS 3,4-METHYLENEDIOXYMETHAMPHETAMINE-INDUCED NEUROTOXICITY IN RAT BRAIN

 
 
Author(s):  MEHDIZADEH MEHDI, DABAGHIAN FATANEH, NEJHADI AKRAM, FALLAH HUSEINI HASSAN, CHOOPANI SAMIRA, SHEKARRIZ NIMA, MOLAVI NIMA, BASIRAT ARGHAVAN, MOHAMMADZADEH KAZORGAH FARZANEH, SAMZADEH KERMANI ALIREZA, SOLEIMANI ASL SARA*
 
* DEPARTMENT OF ANATOMY, FACULTY OF MEDICINE, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, HAMADAN, IRAN
 
Abstract: 
Objective: The spice Zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. The effects of this traditional herbal medicine on 3, 4-methylenediox ymethamphetamine (MDMA) induced neurotoxicity have not yet been studied. The present study considers the effects of Zingiber officinale on MDMA-induced spatial memory impairment and apoptosis in the hippocampus of male rats.
Materials and Methods: In this experimental study, 21 adult male Sprague Dawley rats (200-250 g) were classified into three groups (control, MDMA, and MDMA plus ginger). The groups were intraperitoneally administered 10 mg/kg MDMA, 10 mg/kg MDMA plus 100 mg/kg ginger extract, or 1 cc/kg normal saline as the control solution for one week (n=7 per group). Learning memory was assessed by Morris water maze (MWM) after the last administration. Finally, the brains were removed to study the cell number in the cornu ammonis (CA1) hippocampus by light microscope, Bcl-2 by immunoblotting, and Bax expression by reverse transcription polymerase chain reaction (RT-PCR). Data was analyzed using SPSS 16 software and a one-way ANOVA test.
Results: Escape latency and traveled distances decreased significantly in the MDMA plus ginger group relative to the MDMA group (p<0.001). Cell number increased in the MDMA plus ginger group in comparison to the MDMA group.
Down-regulation of Bcl-2 and up-regulation of Bax were observed in the MDMA plus ginger group in comparison to the MDMA group (p<0.05).
Conclusion: Our findings suggest that ginger consumption may lead to an improvement of MDMA-induced neurotoxicity.
 
Keyword(s): APOPTOSIS, GINGER, SPATIAL MEMORY, MDMA, HIPPOCAMPUS, BCL-2 FAMILY
 
References: 
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