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Paper Information

Journal:   JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES   SPRING 2012 , Volume 20 , Number 1; Page(s) 8 To 17.
 
Paper: 

NEW FORMULATED INSULIN-LOADED NANOLIPOSOMES FOR ORAL DELIVERY: PREPARATION AND IN VIVO EFFICACY

 
 
Author(s):  GHARIB A.*, FAEZIZADEH Z.
 
* DEPT OF LABORATORY SCIENCES, ISLAMIC AZAD UNIVERSITY, BROJERD BRANCH, BROJERD, IRAN
 
Abstract: 

Introduction: The oral insulin delivery is the most familiar, easy and patient friendly of all the routes of insulin applications. The aim of this study was to generate a new chitosan coated insulin nanoliposomes and evaluate their potential for the delivery of insulin.
Materials & Methods: Nanoliposomes encapsulated insulin with negative surface charge was prepared by reverse phase evaporation method. For such a preparation, nanoliposomes lecithin, cholesterol, cetyldiphosphate and
b-cyclodexterin were used. Then, nanoliposomes were coated by means of incubation with the chitosan solution. The encapsulation efficiency of the prepared nanoliposomes was measured by spectrophotometry technique after dissolution of the nanoparticles. The hypoglycemic efficacies of chitosan-coated insulin nanoliposomes were investigated by monitoring the blood glucose level after oral administration to diabetic rabbits.
Findings: Insulin entrapment efficacy for the prepared nanoliposomes by application of the new formulation was significantly (p<0.05) higher (79±0.16) than those of other formulations, respectively. The in vivo result clearly indicated that the insulin loaded nanoliposomes could effectively reduce the blood glucose level in diabetic rabbits.
Discussion & Conclusion: The results clearly suggested that the prepared nanoliposomes could be considered a good candidate for oral insulin delivery.

 
Keyword(s): CHITOSAN, INSULIN, NANOLIPOSOME, ENTRAPMENT EFFICACY
 
 
References: 
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Click to Cite.
APA: Copy

GHARIB, A., & FAEZIZADEH, Z. (2012). NEW FORMULATED INSULIN-LOADED NANOLIPOSOMES FOR ORAL DELIVERY: PREPARATION AND IN VIVO EFFICACY. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 20(1), 8-17. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274298



Vancouver: Copy

GHARIB A., FAEZIZADEH Z.. NEW FORMULATED INSULIN-LOADED NANOLIPOSOMES FOR ORAL DELIVERY: PREPARATION AND IN VIVO EFFICACY. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES. 2012 [cited 2021May14];20(1):8-17. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274298



IEEE: Copy

GHARIB, A., FAEZIZADEH, Z., 2012. NEW FORMULATED INSULIN-LOADED NANOLIPOSOMES FOR ORAL DELIVERY: PREPARATION AND IN VIVO EFFICACY. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, [online] 20(1), pp.8-17. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274298.



 
 
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