Paper Information

Journal:   PROGRESS IN BIOLOGICAL SCIENCES   SUMMER-FALL 2011 , Volume 1 , Number 2; Page(s) 44 To 49.
 
Paper:  PRELIMINARY DATA SUGGEST POSSIBLE ASSOCIATION BETWEEN IL-32 EXPRESSION LEVEL AND TIME OF MS ATTACK
 
Author(s):  ROGHANI MEHRZAD, MAHBOUDI FEREIDOUN, SAHRAIAN MOHAMMAD ALI, ETEMADIFAR MASOUD, ELAHI ELAHE*
 
* DEPARTMENT OF BIOTECHNOLOGY, COLLEGE OF SCIENCE, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 

IL-32 and TNFaare important cytokines in autoimmune and inflammatory diseases. IL-32 has not been previously studied with respect to MS. Here, we report IL-32 and TNFa transcript levels in peripheral blood mononuclear cells of MS patients and control individuals by real time PCR. A significant difference inIL-32 and TNFa mRNA levels of patients as compared to controls was not observed. However, patients with more recent attacks had highly significant increased levels ofIL-32mRNAs. As the sample size was small, this potentially relevant preliminary observation needs to be corroborated using a larger number of patients with well defined clinical features.

 
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