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Paper Information

Journal:   ADVANCES IN COGNITIVE SCIENCE   SPRING 2011 , Volume 13 , Number 1 (49); Page(s) 93 To 100.
 
Paper: 

EFFECTS OF DIFFERENT DOSES OF PENTOXIFYLLINE ON CA1 PYRAMIDAL CELLS OF HIPPOCAMPUS FOLLOWING BRAIN ISCHEMIA IN RATS

 
 
Author(s):  MOVASSAGHI SHABNAM*, SHARIFI ZAHRA NADIA, AKHTARZADEH FATEMEH
 
* ISLAMIC AZAD UNIVERSITY, TEHRAN MEDICAL BRANCH
 
Abstract: 

Objective: Cerebral ischemic/reperfusion causes severe brain damage, especially in CA1 region of hippocampus. Nowadays, vasodilator drugs such as pentoxifylline are considered for their neuroprotective effects, but there is no study on possible neurotrophic effects of this drug and its effective dose on CA1 pyramidal cells of hippocampus in transient global ischemic/reperfusion on experimental models.
Method: In this study male Wistar rats (n=30) in experimental groups 1, 2 and 3 were injected intraperitoneally by 200, 400 and 600 mg/kg pentoxifylline respectively one hour before and one hour after ischemia. Other groups were control, sham and vehicle (normal saline). Four days after ischemia, brains were removed and prepared for histological study (Nissl Method).
Results: Our data showed that there was no significant difference between the number of viable pyramidal cells in CA1 region of hippocampus in control and 200 mg/kg pentoxifylline treated groups.
Conclusion: It seems that the neuroprotective effect of 200 mg/kg pentoxifylline may be accompanied by a reduction of ischemic damage in CA1 region of hippocampus in rats that were subjected to transient global cerebral ischemia.

 
Keyword(s): ISCHEMIA, REPERFUSION, PENTOXIFYLLINE, HIPPOCAMPUS
 
References: 
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