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Paper Information

Journal:   ADVANCES IN COGNITIVE SCIENCE   SPRING 2011 , Volume 13 , Number 1 (49); Page(s) 81 To 92.
 
Paper: 

DOPAMINE D1 AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS MAZE TEST OF ANXIETY

 
 
Author(s):  PIRI MORTEZA*, NASEHI MOHAMAD, POURNAGHSHBAND MAHNAZ, SHAHIN MARYAM SADAT, ZARRINDAST MOHAMMAD REZA
 
* ISLAMIC AZAD UNIVERSITY, ARDABIL BRANCH
 
Abstract: 

Objective: In this study the effects of dopaminergic D1 receptor of dorsal hippocampus on anxiety-like behavior induced by stimulation or inhibition of NMDA receptors were investigated in male Wistar rats.
Method: The elevated plus maze was used in the present study, which is an accepted model to examine anxiety-like behaviors in mice and rats.
Results: The results indicate that intra-CA1injection of MK801 (2
mg/rat) induce anxiolytic effects. Intra-CA1 injection of SCH23390 (0.25, 0.5 and 1 mg/rat) by itself has no effect on anxiety-like behaviors, but administration of same doses of SCH23390 before MK801 (1 mg/rat, intra-CA1) potentiate anxiolytic effects of MK801. On the other hand, intra-CA1 injection of NMDA (0.3 and 0.6 mg/rat) or SKF 38393 (3 and 6 mg/rat) by itself induces anxiogenic effects. Injection of different doses of SKF38393 before NMDA potentiated anxiogenic effects of NMDA.
Conclusion: These results show that both NMDA receptor and dopaminergic D1 receptor not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.

 
Keyword(s): DOPAMINE D1 RECEPTOR, NMDA RECEPTOR, ANXIETY, ELEVATED PLUS MAZE, RATS
 
References: 
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