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Paper Information

Journal:   ADVANCES IN COGNITIVE SCIENCE   SPRING 2011 , Volume 13 , Number 1 (49); Page(s) 81 To 92.
 
Paper: 

DOPAMINE D1 AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS MAZE TEST OF ANXIETY

 
 
Author(s):  PIRI MORTEZA*, NASEHI MOHAMAD, POURNAGHSHBAND MAHNAZ, SHAHIN MARYAM SADAT, ZARRINDAST MOHAMMAD REZA
 
* ISLAMIC AZAD UNIVERSITY, ARDABIL BRANCH
 
Abstract: 

Objective: In this study the effects of dopaminergic D1 receptor of dorsal hippocampus on anxiety-like behavior induced by stimulation or inhibition of NMDA receptors were investigated in male Wistar rats.
Method: The elevated plus maze was used in the present study, which is an accepted model to examine anxiety-like behaviors in mice and rats.
Results: The results indicate that intra-CA1injection of MK801 (2
mg/rat) induce anxiolytic effects. Intra-CA1 injection of SCH23390 (0.25, 0.5 and 1 mg/rat) by itself has no effect on anxiety-like behaviors, but administration of same doses of SCH23390 before MK801 (1 mg/rat, intra-CA1) potentiate anxiolytic effects of MK801. On the other hand, intra-CA1 injection of NMDA (0.3 and 0.6 mg/rat) or SKF 38393 (3 and 6 mg/rat) by itself induces anxiogenic effects. Injection of different doses of SKF38393 before NMDA potentiated anxiogenic effects of NMDA.
Conclusion: These results show that both NMDA receptor and dopaminergic D1 receptor not only play a part in the modulation of anxiety in the dorsal hippocampus of rats but also have demonstrated a complex interaction as well.

 
Keyword(s): DOPAMINE D1 RECEPTOR, NMDA RECEPTOR, ANXIETY, ELEVATED PLUS MAZE, RATS
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

PIRI, M., & NASEHI, M., & POURNAGHSHBAND, M., & SHAHIN, M., & ZARRINDAST, M. (2011). DOPAMINE D1 AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS MAZE TEST OF ANXIETY. ADVANCES IN COGNITIVE SCIENCE, 13(1 (49)), 81-92. https://www.sid.ir/en/journal/ViewPaper.aspx?id=274061



Vancouver: Copy

PIRI MORTEZA, NASEHI MOHAMAD, POURNAGHSHBAND MAHNAZ, SHAHIN MARYAM SADAT, ZARRINDAST MOHAMMAD REZA. DOPAMINE D1 AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS MAZE TEST OF ANXIETY. ADVANCES IN COGNITIVE SCIENCE. 2011 [cited 2021June13];13(1 (49)):81-92. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274061



IEEE: Copy

PIRI, M., NASEHI, M., POURNAGHSHBAND, M., SHAHIN, M., ZARRINDAST, M., 2011. DOPAMINE D1 AND NMDA RECEPTORS INTERACTION IN THE DORSAL HIPPOCAMPUS OF RATS IN THE ELEVATED PLUS MAZE TEST OF ANXIETY. ADVANCES IN COGNITIVE SCIENCE, [online] 13(1 (49)), pp.81-92. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=274061.



 
 
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