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Paper Information

Journal:   JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES   FALL 2012 , Volume 14 , Number 3 (43); Page(s) 104 To 108.
 
Paper: 

EVALUATION OF SERUM HEPATITIS B ANTIBODY LEVEL IN VACCINATED CHILDREN AFTER 14 YEARS IN KASHAN, IRAN

 
 
Author(s):  TAGHAVI ARDAKANI A., SOLTANI B.*, SHARIF M.R., MUSAVI GH.A., KHADEMIAN M.
 
* DEPARTMENT OF PEDIATRIC, KASHAN UNIVERSITY OF MEDICAL SCIENCES, KASHAN, IRAN
 
Abstract: 

Background and Objective: Hepatitis B vaccination has been conducted in neonates in the routine vaccination in Iran since 1993. This study was carried out to evaluate the serum hepatitis B antibody level in vaccinated children after 14 years in Kashan, Iran.
Materials and Methods: This prospetive cohort study was conducted on 200 fourteen-year-old children which were selected via a simple random sampling method in Kashan, Iran drung 2008-09. This subjects were have been vaccined according to the govermental guildline at 0, 2 and 6 months old. Two ml blood specimens were obtained from children and serum hepatitis B surface antibody (anti-HBs) and hepatitis B core antibody (anti-HBc) were determined by ELISA method. Immunity was interpreted as anti-HBs
³10 IU/L. Data were analyzed using SPSS-13, Chi-Square and Fisher’s exat tests.
Results: 92% girls and 95% boys, totally 187 (93.5%) children had serum anti-HBs
³10 IU/L. Anti-HBc was positive in 3 (3%) girls and 5 (5%) boys, totally 8 (4%) which all of them had serum anti-HBS£10 IU/L. No case of positive HBs Ag was detected. Immunity was detected in 11 of 18 (61.1%) children with birth weight<2.5 kg and in 176 of 182 (96.7%) children with birth weight≥2.5 kg (P<0.05).
Conclusion: The immunity following the complete series (0, 2, 6 months old) of hepatitis B vaccination remained detectable after 14 years.

 
Keyword(s): HEPATITIS B, HEPATITIS B VACCINE, ANTI-HBS
 
References: 
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