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Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   FALL 2009 , Volume 16 , Number 3 (SN 53); Page(s) 16 To 20.
 
Paper: 

INVESTIGATION OF INTRON 3 POLYMORPHISM OF P53 IN BREAST CANCER PATIENTS IN ISFAHAN

 
 
Author(s):  FAGHANI M.*, MOHAMMAD GHASEMI F., NASIRI E., NIKBAKHT M.
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE GUILAN UNIVERSITY OF MEDICAL SCIENCES & HEALTH SERVICES, GUILAN, IRAN
 
Abstract: 

Introduction & Objective: Genetic agents play important roles in developing of cancers.
Mutations and polymorphism affects on p53 protein function in suppressing tumor. We aimed to investigate the intron 3 polymorphism of p53 in Isfahanian breast invasive ductal carcinoma.
Materials & Methods: We undertook a case-control study on 192 controls and 192 patients with breast invasive ductal carcinoma from Isfahan. p53 intron 3 genotypes were identified using allele-specific PCR. The X2-test was used to assess the statistical significance of the data.
Results: In control samples, the genotype distribution for p53 intron 3 polymorphisms was 57.3% and 42.7% for the A1/A2 and A1/A1 genotypes, respectively. In the cancer group, 85.4% of the cases were A1/A2 and 14.6%were A1/A1. The differences in the distribution of the p53 intron 3 polymorphism between the cases and controls were statistically significant (P<0.001).
Conclusion: Our findings indicated that p53 intron 3 polymorphism probably is a genetic predisposing factor for breast invasive ductal carcinoma development in Isfahanian specimens.

 
Keyword(s): BREAST NEOPLASMS, INTRON 3, P53 TUMOR SUPPRESSOR GENE, POLYMORPHISM
 
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