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Paper Information

Journal:   AVICENNA JOURNAL OF CLINICAL MEDICINE (SCIENTIFIC JOURNAL OF HAMADAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES)   FALL 2009 , Volume 16 , Number 3 (SN 53); Page(s) 5 To 11.
 
Paper: 

COMPARING IL-5, IL-10,IL-12, AND IL-18 CYTOKINES LEVELS SECRETED FROM THE PBMCS OF PATIENTS WITH HEALING AND NONHEALING SKIN LEISHMANIASIS

 
 
Author(s):  MOHAJERI M.*, SHAMSIAN S.A., NAHRAVANIAN H., MAHMOUDI M., YAZDANPANAH S.M.J, FATHI MOGHADAM F., SHAHI M.
 
* DEPARTMENT OF PARASITOLOGY, SCHOOL OF MEDICINE MESHED UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, MESHED, IRAN
 
Abstract: 
Introduction & Objective: Leishmaniasis is a major worldwide health problem throughout the world and in Iran as well. Skin lesions are mostly healing but nonhealing cases have also increased recently. T-helper typel (Thl) responses induction helps the patients to resist against the disease while T-helper type2 (Th2) responses cause susceptibility to disease. With the assessment of IL-5, IL-10, IL-12, and IL-18 cytokines secreted from peripheral blood mononuclear cells (PBMC) in leishmaniasis healing and nonhealing patients, their role in curing leishmaniasis was surveyed.
Materials & Methods: Cytokines secreted from PBMCs of 60 healing and nonhealing patients and also control group referred to Ab-o-Bargh number! clinic and Mashhad Qaem hospital during 2007 were evaluated Elisa commercial kits after stimulation by leishmania antigen and mitogen in vitro.
Results: Healing patients PBMCs secreted IL-12 (236.55
±38.00pg/ml) more than nonhealing patients (p<0.05) while in nonhealing patients IL-5 (52.14±65.21pg/ml) and IL-I0 (30.19±18.73 pg/ml) secreted more than healing patients (p<0.005). Also IL-18 secreted significantly higher in nonhealing patients compared with healing patients (p=0.003).
Conclusion: According to the results It can be concluded that IL-12 is secreted more in healing patients than nonhealing patients but IL-18, which causes the increase of IL-12 secretion and the activation of Thl cells during IL-12 secretion decrease, secrets more in nonhealing patients, induces Th2 responses and results in disease progression.
 
Keyword(s): CYTOKINES, LEISHMANIASIS, SKIN LESIONS
 
References: 
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