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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 88 To 88.
 
Paper: 

ORAL PRESENTATIONS: INFERTILITY AND PREGNANCY OUTCOME IN FEMALE GENITAL TUBERCULOSIS

 
 
Author(s):  TAHERKHANI S.*
 
* FACULTY OF NURSING AND MIDWIFERY, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Tuberculosis of the genital tract is one of the major causes of gynecological morbidity. Genital TB affects about 12% of patients with pulmonary tuberculosis and represents 15-20% of extrapulmonary tuberculosis. Genital TB may be asymptomatic but involves genital organs such as fallopian tubes, endometrium, ovaries, cervix, vulva/ vagina and myometrium. The major presenting symptom in young women with genital TB is infertility. This study designed to determine infertility and pregnancy outcome in female genital tuberculosis.
Materials and Methods: This is a systematic review article, the newest scientific references was used for data gathering.
Results: After treat with antituberculous chemotherapy, overall conception rate is very poor. It varies from 10 to 20% throughout the world, the risk of ectopic pregnancy and miscarriage is increased in those in whom conception does take place. Traditional treatments for infertility such as surgical correction of anatomical distortions of the uterus and tubal damage, or induced ovulation yield low success rates. Results have also supported the use of IVF-ET as a successful method for treating infertility of tuberculous origin. The success of IVF-ET depends, however, upon the extent of endometrial involvement. The results are generally dismal in the presence of extensive fibrosis and adhesions. Otherwise Mycobacterium tuberculosis, prior to developing into active tubercular endometritis, may reside in the basal endometrium leading to impairment of the endometrial and sub-endometrial blood flow (SEBF). Hence, implantation failure following IVF in women with apparently normal pelvic and nonendometrial tubal factors, absence of adhesions, and age< 35 years could be attributed to latent tuberculosis, thus use of PCR and Doppler parameters together in order to assess endometrial receptivity may often prove to be cost-effective as compared to the high price tag associated with repeated IVF attempts.
Conclusion: For the treatment of infertility of tuberculous origin, IVF-ET was the most successful modality. Genital tuberculosis especially latent genital TB still remains a much neglected area of research.

 
Keyword(s): INFERTILITY, IN VITRO FERTILIZATION, PREGNANCY OUTCOME, FEMALE GENITAL TUBERCULOSIS, LATENT TUBERCULOSIS
 
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