Paper Information

Journal:   IRANIAN JOURNAL OF DERMATOLOGY   SPRING 2012 , Volume 15 , Number 1 (59); Page(s) 1 To 3.
 
Paper:  THE ROLE OF STAPHYLOCOCCUS SUPER ANTIGENS IN CHRONIC PLAQUE TYPE PSORIASIS
 
Author(s):  ATEFI NAJMOSADAT, TABAIE MEHDI*, NOORBAKHSH SAMILEH, TABATABAIE AZARMIDOKHT, REZAEE MOHAMMADREZA, ROHANINASAB MASOMEH
 
* DEPARTMENT OF DERMATOLOGY, HAZRAT-E RASOOL UNIVERSITY HOSPITAL, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 
Background: T cell activation is discussed as an important factor in the pathogenesis of psoriasis. Recently, a lot of attention has been paid to the role of super antigens in T cell activation in the pathogenesis of psoriasis. In this study, the role of staphylococcal super antigens in the pathogenesis of psoriasis with identification of staphylococcal toxin levels in the skin lesions of patients with chronic plaque psoriasis has been studied.
Method: In this case-control study, biopsies were taken from the skin of 40 patients with chronic plaque type psoriasis and 40 controls.
Staphylococcal super antigens such as staphylococcus enterotoxin A, staphylococcus enterotoxin C, and toxic shock syndrome toxin 1 were investigated using polymerase chain reaction.
Result: Staphylococcus aureus was isolated from 6.5% of the psoriasis patients and 2.5% of the individuals in the control group and all of them were toxin producer. There was a significant difference between controls and patients.
Conclusion: Bacterial super antigens probably play an important role in the pathogenesis of chronic plaque type psoriasis.
 
Keyword(s): POLYMERASE CHAIN REACTION, PSORIASIS, STAPHYLOCOCCUS AUREUS, SUPERANTIGE
 
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