Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   JANUARY 2011 , Volume 18 , Number 91; Page(s) 27 To 35.
 
Paper: 

EFFECT OF SIMVASTATIN ON HEALING OF EXPERIMENTAL FEMORAL CORTICAL BONE DEFECT IN RATS

 
 
Author(s):  MOHAJERI DARYOUSH*, MOUSAVI GHAFOUR, REZAIE ALI, ALIMOHAMADI ARMIN
 
* DEPARTMENT OF PATHOBIOLOGY, FACULTY OF VETERINARY MEDICINE, TABRIZ BRANCH, ISLAMIC AZAD UNIVERSITY, TABRIZ, IRAN
 
Abstract: 

Background: Rebuilding and renovation of lost bone whether because of physiologic or pathologic factors was one of the surgeons’ motivations from the past. Statins are commonly prescribed cholesterol-lowering drugs; however, it has recently been shown that they also have the beneficial side effect of enhancing bone matrix formation. As a result, this study evaluates the possible osteogenic effect of Simvastatin on the experimental femoral defect in rats.
Methods: This experimental study was conducted on 30 male SD rats. Animals were divided randomly into 3 groups (control and experimental). After induction of general anesthesia, a 2mm hole was made using a dental bit in the width of the femur reaching the medullary channel. After surgery, the control group received orally physiological serum daily and experimental groups 1 and 2 respectively received daily 10 and 20 mg/kg/PO of Simvastatin. Histopathological and histomorphometrical studies for evaluation of bone healing were carried out in experimental rats, which were euthanized after 45 days of the experiment using hematoxylin-eosin (H&E) staining method. For data analysis ANOVA and Tukey tests along with SPSS version 18 was used.
Results: In control group, defect seemed to be filled with woven bone and bone marrow spaces in spite of a poor osteogenic activity. In experiment groups, young bone trabeculae had increased in number and were more organized. Histomorphometric results observed that Simvastatin has significant effect on bone healing in experimental groups 2 and 3 than control group, but no significant effect was observed between groups that received low and high dosage of simvastatin.
Conclusion: The results of this study show that Simvastatin could stimulate osteogenesis in rats.

 
Keyword(s): SIMVASTATIN, BONE HEALING, RAT, HISTOPATHOLOGY, HISTOMORPHOMETRY
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 71
 
Latest on Blog
Enter SID Blog