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Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   NOVAMBER 2011 , Volume 18 , Number 89; Page(s) 46 To 53.
 
Paper: 

INVESTIGATION OF SERUM C-REACTIVE PROTEIN AND MANNOSE-BINDING LECTIN LEVELS IN PATIENTS WITH DERMATOPHYTOSIS

 
 
Author(s):  NAMI SANAM, FALAHATI MEHRABAN*, ZEINI FARIDEH, AKHLAGHI LAME, SADRI MOHAMMAD, TABATABAIE FATEMEH, GHASEMI ZEINAB, NOZARI SHIMA
 
* MEDICAL SCHOOL, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Dermatophytosis is common cutaneous fungal disease with worldwide distribution. Interleukin8 (IL-8) realized from keratinocytes in the presence of dermatophytic antigens causes induction of acute responses in dermatophyte infection and subsequently production of acute phase proteins occurs in hepatocytes. C-reactive protein (CRP) and Mannose-binding lectin (MBL) are acute phase proteins. Since few researches in the case of acute phase proteins in dermatophytic infections has been accomplished, this study has been designed for determining serum CRP and MBL levels in patients affected to dermatophytosis.
Methods: This was a cross sectional study and samples were carried out on 96 healthy individuals and 105 patients affected to dermatophytosis with non probable and in access procedure. For isolation and identification of dermatophyte direct microscopic examination, culturing and complementary examinations were done and for determination of serum CRP and MBL levels in healthy individuals and in patients ELISA test were used. For investigation of relevance between variables, Chi-square, Fisher exact, Mann-Whitney and Roc curve analysis were used and p< 0.05 was considered as meaningful level.
Results: The median serum CRP level in healthy individuals and in patients group was 3.31±3.32
mg/ml and 16.60±35.96 mg/ml (p<0.001) respectively and the median serum MBL level was 1.53±1.87 mg/ml and 1.97±2.03 mg/ml (p=0.039) respectively. CRP (p<0.001) and MBL (p=0.042) were determined meaningful parameters for dermatophytosis. MBL deficiency (MBL concentrations <1 mg/ml) was higher in control subjects (56.2%) than in patients (41.0%).
Conclusion: Findings of this study indicate increased concentrations of CRP and MBL in patients affected to dermatophytosis and their role in this infection. Probably observation of high frequency of MBL deficiency in healthy individuals in compare with patients group indicates that it is not predisposing factor in affecting to dermatophytosis.

 
Keyword(s): DERMATOPHYTOSIS, CRP, MBL
 
References: 
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