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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 79 To 79.
 
Paper: 

GENETICS: POLYMORPHISMS IN THE 5’ UPSTREAM REGION OF THE FSH RECEPTOR GENE, AND THEIR ASSOCIATION WITH SUPEROVULATION TRAITS IN CHINESE HOLSTEIN COWS

 
 
Author(s):  YANG W.*, LI SH., TANG K., HUA G., ZHANG CH., YU J., HAN L., YANG L.
 
* COLLEGE OF ANIMAL SCIENCE AND TECHNOLOGY, HUAZHONG AGRICULTURAL UNIVERSITY, HUAZHONG AGRICULTURAL UNIVERSITY, WUHAN, CHINA
 
Abstract: 

Background: The major limitation to the development of embryo transfer technique in cattle is the highly variable between individuals in ovulatory response to FSH-induced superovulation. The objective of this study was to identify a predictor to forecast superovulation response on the basis of associations between superovulation performance and gene polymorphism.
Materials and Methods: PCR-single-strand conformational (PCR-SSCP) and DNA sequencing were used to find variation in the bovine follicle stimulating hormone receptor (FSHR) gene in 118 Chinese Holstein cows treated for superovulation.
Results: One single nucleotide polymorphism (SNP) of G-278A located in the 5’ upstream region of bovine FSHR gene was found in 118 Chinese Holstein cows treated for superovulation. Two SNPs of G-278A (GU253337) and A-320T (rs43676359) were analyzed. In polymorphic locus −278, all cows without superovulation response were mutations with genotypes of CD and DD. Cows with CC genotype had a significant increase in the total number of ova (TNO) (p<0.01), and produced more transferable embryos (NTE) than those of the CD and DD genotypes (p<0.01). At this locus, the additive effects seemed to be highly significant (p<0.01) and allele C was associated with an increase in the TNO and NTE.
Conclusion: These results indicated that the FSHR is a potential marker for superovulation response and can be used as a predictor for superovulation in Chinese Holstein cows.

 
Keyword(s): CHINESE HOLSTEIN COW, FSHR GENE, SNP SUPEROVULATION
 
 
References: 
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Citations: 
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APA: Copy

YANG, W., & LI, S., & TANG, K., & HUA, G., & ZHANG, C., & YU, J., & HAN, L., & YANG, L. (2011). GENETICS: POLYMORPHISMS IN THE 5’ UPSTREAM REGION OF THE FSH RECEPTOR GENE, AND THEIR ASSOCIATION WITH SUPEROVULATION TRAITS IN CHINESE HOLSTEIN COWS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 5(SUPPLEMENT 1), 79-79. https://www.sid.ir/en/journal/ViewPaper.aspx?id=273167



Vancouver: Copy

YANG W., LI SH., TANG K., HUA G., ZHANG CH., YU J., HAN L., YANG L.. GENETICS: POLYMORPHISMS IN THE 5’ UPSTREAM REGION OF THE FSH RECEPTOR GENE, AND THEIR ASSOCIATION WITH SUPEROVULATION TRAITS IN CHINESE HOLSTEIN COWS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2011 [cited 2021August04];5(SUPPLEMENT 1):79-79. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=273167



IEEE: Copy

YANG, W., LI, S., TANG, K., HUA, G., ZHANG, C., YU, J., HAN, L., YANG, L., 2011. GENETICS: POLYMORPHISMS IN THE 5’ UPSTREAM REGION OF THE FSH RECEPTOR GENE, AND THEIR ASSOCIATION WITH SUPEROVULATION TRAITS IN CHINESE HOLSTEIN COWS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 5(SUPPLEMENT 1), pp.79-79. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=273167.



 
 
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