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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 74 To 74.
 
Paper: 

GENETICS: PHOSPHOLIPASE C ZETA: AS AN INDEX TO ASSESS FERTILIZATION POTENTIAL OF A SEMEN SAMPLE

 
 
Author(s):  AGHAJANPOUR S.*, GHAEDI K., SALAMIAN A., TAVALAEE M., DEEMEH M.R., NASR ESFAHANI M.H.
 
* DEPARTMENT OF BIOLOGY, SCHOOL OF SCIENCES, UNIVERSITY OF, ISFAHAN, IRAN
 
Abstract: 

Background: Failed fertilization post ICSI has been mainly attributed to the sperm’s inability to induce oocyte activation. Phospholipase C Zeta (PLCz) is considered to be a primary factor for the induction of oocyte activation. The aim of this study was to quantitatively assess the expression of PLCz in globozoospermic or individuals with previous low or failed fertilization in comparison to fertile or individuals with high fertilization potential.
Materials and Methods: Real-time PCR was carried out to evaluate relative expression of PLC
z mRNA.
Results: The expression of PLC
z was significantly lower in globozoospermic men or individuals with previous low or failed fertilization in comparison to fertile individuals or those with high fertilization. Significant correlation was observed between relative expression of PLCz and fertilization rate.
Conclusion: In this study, for the first time, we have shown that assessment of relative expression of PLC
z appears to provide a good index for quantitative assessment of the potential for a semen sample to induce oocyte activation.

 
Keyword(s): FAILED FERTILIZATION, PLCϚ, CROSIN ACTIVITY, PROTAMINE, ICSI
 
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