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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 72 To 73.
 
Paper: 

FEMALE INFERTILITY: INTERLEUKIN 6, INTERLEUKIN 1β, ESTRADIOL AND TESTOSTERONE CONCENTRATIONS IN SERUM AND FOLLICULAR FLUID OF FEMALES WITH STIMULATED AND NON-STIMULATED OVARIES

 
 
Author(s):  SHEIKH N., AMIRI I.*, FARIMANI M., YAVANGI M., RABIEE S., GHORBANI M.
 
* FATEMIEH INFERTILITY RESEARCH CENTER, SCHOOL OF MEDICINE, HAMADAN UNIVERSITY OF MEDICAL SCIENCES, HAMADAN, IRAN
 
Abstract: 

Background: The ovarian physiology is regulated by a complex of factors such as hormones and growth factors. The hormones and growth factors synthesized by follicular and ovarian cells during follicular maturation stage and cytokines synthesized by immune system. Interaction between immune and endocrine systems modulates ovarian function through the secretion of regulatory soluble factors, especially cytokines. There is a close contact between corona-cumulus-oocyte complexes with follicular fluid which effects on the quality and degree of oocyte maturation. The objectives of the present study were to determine the levels of Interleukin-6 (IL-6), Interleukin 1 b, estradiol and testosterone concentration in serum and follicular fluid of women with stimulated and non-stimulated ovaries.
Materials and Methods: A total of 41 women, 27 in stimulated and 14 non-stimulated cycles, undergoing Intra cytoplasmic sperm injection (ICSI) treatment were included in this study. Follicular fluid and serum samples from all cases were collected at the time of oocyte retrieval and concentration of testosterone, estradiol, interleukin 6 and interleukin 1
b were measured.
Results: The results showed that serum concentration of testosterone was significantly higher in non-stimulated cases. Also, the serum and follicular fluid concentrations of interleukin 6 and interleukin 1
b in stimulated cases were significantly higher than non-stimulated group. There was an important negative correlation between the level of testosterone in patient's serum and IL-6 and IL-1 b levels of follicular fluid.
Conclusion: According, to these results it seems that the levels of testosterone and IL-6 and IL-1
b in patient's serum and follicular fluid are a good factor for prediction of maturity of oocytes.

 
Keyword(s): OOCYTE MATURATION, FOLLICULAR FLUID, INTERLEUKIN 6, INTERLEUKIN 1β, TESTOSTERONE, ESTRADIOL
 
 
References: 
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Click to Cite.
APA: Copy

SHEIKH, N., & AMIRI, I., & FARIMANI, M., & YAVANGI, M., & RABIEE, S., & GHORBANI, M. (2011). FEMALE INFERTILITY: INTERLEUKIN 6, INTERLEUKIN 1β, ESTRADIOL AND TESTOSTERONE CONCENTRATIONS IN SERUM AND FOLLICULAR FLUID OF FEMALES WITH STIMULATED AND NON-STIMULATED OVARIES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 5(SUPPLEMENT 1), 72-73. https://www.sid.ir/en/journal/ViewPaper.aspx?id=273062



Vancouver: Copy

SHEIKH N., AMIRI I., FARIMANI M., YAVANGI M., RABIEE S., GHORBANI M.. FEMALE INFERTILITY: INTERLEUKIN 6, INTERLEUKIN 1β, ESTRADIOL AND TESTOSTERONE CONCENTRATIONS IN SERUM AND FOLLICULAR FLUID OF FEMALES WITH STIMULATED AND NON-STIMULATED OVARIES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2011 [cited 2021May12];5(SUPPLEMENT 1):72-73. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=273062



IEEE: Copy

SHEIKH, N., AMIRI, I., FARIMANI, M., YAVANGI, M., RABIEE, S., GHORBANI, M., 2011. FEMALE INFERTILITY: INTERLEUKIN 6, INTERLEUKIN 1β, ESTRADIOL AND TESTOSTERONE CONCENTRATIONS IN SERUM AND FOLLICULAR FLUID OF FEMALES WITH STIMULATED AND NON-STIMULATED OVARIES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 5(SUPPLEMENT 1), pp.72-73. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=273062.



 
 
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