Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 72 To 72.
 
Paper: 

FEMALE INFERTILITY: PROLIFERATIVE ACTIVITY OF MUCOSAL AND MUSCULAR LAYERS IN MOUSE OVIDUCT FOLLOWING ADMINISTRATION OF EXOGENOUS MELATONIN

 
 
Author(s):  SEYEDSAADAT S.N.*, KHAJEH JAHROMI S., HOMAFAR M.A., HAJIZADEH FALLAH H., MOHAMMAD GHASEMI F.
 
* STUDENT RESEARCH COMMITTEE, GUILAN UNIVERSITY OF MEDICAL SCIENCES, RASHT, IRAN
 
Abstract: 

Background: Melatonin, a pineal hormone, is considered as a powerful antioxidant agent. It could be effective on cell cycle and cell differentiation. The aim of this study was to evaluate the effect of exogenous melatonin on proliferative activity of mucosal and muscular layers in mouse oviduct.
Materials and Methods: Female adult NMRI mice were divided into 3 groups. Animals in control were received ethanol /saline and the other animals in groups of 2 and 3 were treated with 5 mg/kg and 10 mg/kg melatonin respectively. All animal were treated for 5 consecutive days intraperitoneally. After autopsy on 15th day, Evaluations were made by ki-67 Immunohistochemistry staining for proliferative activity of the cells in mucosal and muscular layers of tubes and ELISA for assay of serum estradiol levels. Statistical analysis was performed using ANOVA test.
Results: The mean numbers of Ki-67 positive cells in mucosal and muscular layers in controls were 2 ± 2.08 and 0.96 ± 1.10 respectively. Serum estradiol levels in controls were 80.53 ng/dl. Administration of melatonin in doses of 5 mg/kg and 10mg/kg for 5 days could not alter the proliferative activity of the cells both in mucosal and muscular layers of oviduct in groups of 2 and 3 compared with controls. Serum estradiol levels were not significant between groups.
Conclusion: On the basis of this study, Administration of exogenous melatonin in doses of 5 mg/kg and 10 mg/kg for the 5 consecutive days in adult female mouse is not associated with alterations in proliferative activity of the mucosal and muscular layers of oviduct.

 
Keyword(s): EXOGENOUS MELATONIN, OVIDUCT, ESTRADIOL LEVEL
 
References: 
  • ندارد
 
  Yearly Visit 43
 
Latest on Blog
Enter SID Blog