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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 63 To 63.
 
Paper: 

EPIDEMIOLOGY AND ETHICS: EVALUATION OF OVARIAN TOXICITY EFFECTS OF CHLORPROMAZINE IN FEMALE RATS

 
 
Author(s):  ZAMANI Z.*, ZARE S., AHMADI A., SADRKHANLOU R., MOVAHED E.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCE, URMIA UNIVERSITY, URMIA, IRAN
 
Abstract: 

Background: Elevations in serum prolactin levels (hyperprolactinaemia) are a common side effect of conventional antipsychotic treatments. The main objective of this study was to consider the effects of the antipsychotic drug chlorpromazine (CPZ) in female rat’s reproductive system and to examine the relationship between the effects on reproductive organs and hormone concentrations.
Materials and Methods: In this study fourty adult female wistar rats (160 ± 20g) were randomly divided into five groups (n=8 each) with one group serving as control that received only food and water,and one group serving as control sham((5 mL/kg of 0.5% methylcellulose solution.), in the drug treated groups female rats were orally administered CPZ (3, 10, 30 mg/kg) once daily (7 days/week) for 4 weeks. The test compound was suspended or dissolved in 0.5% methylcellulose solution. All rats were sacrificed by Co2 inhalation one day after the last drog administration. The reproductive organs were removed surgically and prepared for histological study.
Results: This study showed that treated by CPZ had significant increase in prolactin level in plasma, because of high activity of prolactin on ovary spesially on luteotropic which cause in the female reproductive organs, enlarged corpora lutea and significantly increased antral and preantral atretic follicles number in the ovary, atrophy in the uterus and epithelial mucification in the vagina were obviuse.
Conclusion: These results showed that oral CPZ treatment indused ovarian toxicity including increase in atresia of the large follicles and changed the fertility parameters.

 
Keyword(s): CLROPROMAZINE, PROLACTIN, HYPERPROLACTINAEMIA, LOTEOTROP, ATRESEA
 
 
References: 
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Click to Cite.
APA: Copy

ZAMANI, Z., & ZARE, S., & AHMADI, A., & SADRKHANLOU, R., & MOVAHED, E. (2011). EPIDEMIOLOGY AND ETHICS: EVALUATION OF OVARIAN TOXICITY EFFECTS OF CHLORPROMAZINE IN FEMALE RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 5(SUPPLEMENT 1), 63-63. https://www.sid.ir/en/journal/ViewPaper.aspx?id=273010



Vancouver: Copy

ZAMANI Z., ZARE S., AHMADI A., SADRKHANLOU R., MOVAHED E.. EPIDEMIOLOGY AND ETHICS: EVALUATION OF OVARIAN TOXICITY EFFECTS OF CHLORPROMAZINE IN FEMALE RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2011 [cited 2021May10];5(SUPPLEMENT 1):63-63. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=273010



IEEE: Copy

ZAMANI, Z., ZARE, S., AHMADI, A., SADRKHANLOU, R., MOVAHED, E., 2011. EPIDEMIOLOGY AND ETHICS: EVALUATION OF OVARIAN TOXICITY EFFECTS OF CHLORPROMAZINE IN FEMALE RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 5(SUPPLEMENT 1), pp.63-63. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=273010.



 
 
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