Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   MARCH 2012 , Volume 18 , Number 93; Page(s) 8 To 14.
 
Paper: 

COMPARISION OF ANTIFUNGAL EFFECT OF FLUCONAZOLE ALONE AND IN COMBINATION WITH NANOSILVER PARTICLES AGAINST CANDIDA SPECIES ISOLATED FROM CHRONIC CANDIDAL VULVOVAGINITIS

 
 
Author(s):  NOZARI SHIMA, HAYDARI KOHAN FARIBA, ASHRAFI KHOZANI MAHTAB, AHMADI FARZANEH, GHASEMI ZEINAB, NAMI SANAM, FALAHATI MEHRABAN*
 
* MEDICINE FACULTY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Candidal vulvovaginitis is a female genital infection that is occurred by the over growth of candida species and specially Candida -albicans and occasionally it appears as recurrent and chronic and resist to therapy. Fluconazole is one of the current drugs that is used in treatment of this disease and sometimes resistance is observed to this. Therefore indirection of making the therapy better we decided to investigate the activity of fluconazole in combination with silver nanoparticles against candida species isolated from chronic and recurrent candida vaginitis.
Methods: This was an experimental study with convenient sampling that was performed on 30 patients. All specimens were examined in direct microscopy, culturing and differential tests to identify different candida species from each other such as culture on candida chrome agar, germ tube, temperature test and sugar assimilation with API. Then the antifungal effects of fluconazole and silver nanoparticles, each of them alone and in combination with each other, were examined. Findings were described on the base of logistic regression and man-vitni exam.
Results: In our study 30 specimens of chronic genital candidiasis were diagnosed with isolated agents Candida albicans, glabrata, krusei, tropicalis, parapsilosis and Candida fermata respectively. Also findings suggested that fluconazole was able to inhibit the growth of candida species at an expanded range of concentration between 4-128 microgram per milliliter. As well antifungal activity of Fluconazole with silver nanoparticles was increased in comparison with using Fluconazole alone.
Conclusion: For the prevention of recurrent cases and to establish correct diagnosis it is essential to carry out sensitivity and diagnostic tests in laboratory and also administration of silver nanoparticle in combination with fluconazole in drug formulation for topical uses in treatment of chronic vaginal candidiasis and inhibition of recurrent cases, can useful.

 
Keyword(s): FLUCONAZOLE, NANOSILVER, ANTIFUNGAL SUSCEPTIBILTY, SYNERGISM, CANDIDA SPECIES
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 57
 
Latest on Blog
Enter SID Blog