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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 55 To 55.
 
Paper: 

EPIDEMIOLOGY AND ETHICS: COMPARISON OF OXIDATIVE STRESS AND ANTIOXIDATIVE STATUS IN NON-OBESE WOMEN WITH AND WITHOUT POLYCYSTIC OVARY SYNDROME

 
 
Author(s):  AALI B.SH.*, GHOLAMHOSEINIAN A., NAKHAEE N., BAGHERI F.
 
* DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, KERMAN MEDICAL UNIVERSITY, KERMAN, IRAN
 
Abstract: 

Background: Polycystic ovary syndrome is a common endocrine disorder in women with variable clinical presentation and abnormalities such as chronic anovulation, hyperandrogenism and infertility. The etiology is unknown, however, in the recent years some researchers have focused on oxidative status in these patients. As obesity is a common characteristic in this syndrome and a relationship between obesity and oxidative stress has been identified, the present study was carried out to determine the relationship between oxidative stress and PCOS per se by comparing the level of oxidant and anti-oxidants substances in non-obese women with polycystic ovaries and normal women.
Materials and Methods: This case control study was carried on 29 non-obese (BMI
£ 25) women with polycystic ovary syndrome and 100 non-PCOS women aging 17-40 years, matched for BMI at gynecology clinic of Afzalipoor Hospital. Malonyldialdehyde (MDA) as a representative of total oxidative status (TOS) and total antioxidant status (TAS) levels were compared in the groups using t-test. Spearman test was utilized to understand the correlation between the variables.
Results: In this study, neither the logarithm of mean malonyldialdehyde (1. 29 ± 0.5 in PCOS vs. 1.25 ± 0.3 in control group) nor the log of mean TAS (0.48 ± 0.07 in PCOS and 0.48 ± 0.08 in the control group, respectively) differed significantly in the groups. However, the mean of MDA revealed a significantly positive correlation with TSH (r = 0.5), while mean of TAS had negetive correlation with FSH (r=-0.7, p=0.002).
Conclusion: Oxidative status is not different in on-obese women with and without PCOS. It is postulated that the higher level of oxidant substances in PCOS patients is reflective of concomitant obesity rather than PCOS per se.

 
Keyword(s): OXIDATIVE STRESS, ANTIOXIDANT STATUS, PCOS, NON OBESE
 
 
References: 
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APA: Copy

AALI, B., & GHOLAMHOSEINIAN, A., & NAKHAEE, N., & BAGHERI, F. (2011). EPIDEMIOLOGY AND ETHICS: COMPARISON OF OXIDATIVE STRESS AND ANTIOXIDATIVE STATUS IN NON-OBESE WOMEN WITH AND WITHOUT POLYCYSTIC OVARY SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 5(SUPPLEMENT 1), 55-55. https://www.sid.ir/en/journal/ViewPaper.aspx?id=272658



Vancouver: Copy

AALI B.SH., GHOLAMHOSEINIAN A., NAKHAEE N., BAGHERI F.. EPIDEMIOLOGY AND ETHICS: COMPARISON OF OXIDATIVE STRESS AND ANTIOXIDATIVE STATUS IN NON-OBESE WOMEN WITH AND WITHOUT POLYCYSTIC OVARY SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2011 [cited 2021August03];5(SUPPLEMENT 1):55-55. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272658



IEEE: Copy

AALI, B., GHOLAMHOSEINIAN, A., NAKHAEE, N., BAGHERI, F., 2011. EPIDEMIOLOGY AND ETHICS: COMPARISON OF OXIDATIVE STRESS AND ANTIOXIDATIVE STATUS IN NON-OBESE WOMEN WITH AND WITHOUT POLYCYSTIC OVARY SYNDROME. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 5(SUPPLEMENT 1), pp.55-55. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272658.



 
 
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