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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 41 To 41.
 
Paper: 

ANDROLOGY: THE EFFECTS OF HYDROALCOHOLIC EXTRACT OF LEPIDIUM SATIVUM(L.S) ON SPERM PARAMETERS IN ADULT RAT

 
 
Author(s):  FAGHANI M.*, MOHAMMADGHASEMI F., KIAHI G., NASRI S.
 
* CELLULAR AND MOLECULAR RESEARCH CENTER, GUILAN UNIVERSITY OF MEDICAL SCIENCE, RASHT, IRAN
 
Abstract: 

Background: The aim of this study was to investigate the effects of hydroalcoholic extract of lepidium sativum(LS) on sperm parameters in adult rat.
Materials and Methods: Male adult rats were divided into three groups: control group (n=5) received normal salin; group2: received 200 L.S extract; group3: received 400 LS extract. All groups were treated for 21 days. Evaluations were made by hystomorphometeric analysis and assay of plasma testosterone level.
Results: Lepidium sativum in both dosages 200 and 400 of caused to reduction in germinal epithelial thickness and tube diameters in siminiferous tubules (p<0.05). A significant decrease of serum testosterone level was observed in both dosages of 200 and 400 L.S groups (p<0.05).
Conclusion: We conclude that hydroalcoholic extract of lepidium sativum in dosage of 200 and 400 for 3 weeks has toxic effect on testicular tissue and quality of spermatogenesis and probably it could be due to hypophis-gonadal axis alterations.

 
Keyword(s): SPERM PARAMETERS, LEPIDIUM SATIVUM, RAT
 
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