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Paper Information

Journal:   IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES   JULY-AUGUST 2012 , Volume 15 , Number 4; Page(s) 958 To 964.
 
Paper: 

EFFECT OF VITAMIN SUPPLEMENTATION ON SERUM OXIDIZED LOW-DENSITY LIPOPROTEIN LEVELS IN MALE SUBJECTS WITH CARDIOVASCULAR DISEASE RISK FACTORS

 
 
Author(s):  NAJAFPOUR BOUSHEHRI SAEID*, MOHAMMAD YUSOF ROKIAH, MOHAMMAD TAIB MOHAMMAD NASIR, MIRZAEI KAMRAN, YAZDEKHASTI NARGES, AKBARZADEH SAMAD
 
* FACULTY OF HEALTH, BUSHEHR UNIVERSITY OF MEDICAL SCIENCES, BUSHEHR, IRAN
 
Abstract: 

Objective(s): Oxidized low-density lipoproteins (ox-LDLs) appear to play a significant role in atherogenesis. In fact, circulating ox-LDL concentrations have been recognized as a risk factor for cardiovascular disease (CVD). The main objectives of this study were to assess the effects of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD risk factors.
Materials and Methods: The effect of antioxidant vitamins on ox-LDL as a biomarker of CVD in male subjects with CVD in male subjects with CVD risk factors at baseline and after 12 weeks of supplementation with vitamin E (400 IU), C (500 mg),
b-carotene (15 mg), and the combined supplements (E, C, and b-carotene) respectively defined as group E, C, B and control group was considered as group P.
Results: The mean values for ox-LDL at the baseline were 86.93±26.30 U/l in group C, 94.52±38.40 U/l in group E, 79.73±2.07 U/l in group B, 85.97±23.07 U/l in combined group, and 84.90±14.66 U/l in group P. After 12 weeks of intervention the percentage of changes for group C, group E, group B, COM group, and group P were (-18.32), (-2286), (-17.31), (-19.01) and (-2.0), respectively. Using Wilcoxon method, significant differences were detected in the mean ox-LDL concentrations of baseline and after intervention, values in the C, E, B and combined groups (P<005).
Conclusion: This study illustrated that diet supplemented with vitamin C (500 mg), vitamin E (400 IU),
b-carotene (15 mg), and the combination of these vitamins was associated with lower serum ox-LDL levels.

 
Keyword(s): CARDIOVASCULAR DISEASES, OXIDIZED LOW-DENSITY LIPOPROTEIN, VITAMIN E, VITAMIN C, β-CAROTENE
 
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