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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2012 , Volume 6 , Number SUPPLEMENT 1; Page(s) 137 To 138.
 
Paper: 

DOES CIPROFLOXACIN EXERT SEVERE OXIDATIVE STRESS IN TESTICULAR TISSUE?

 
 
Author(s):  ZOBEIRI F.*, SADRKHANLOU R.A., RAZI M., MOKARIZADEH A.
 
* DEPARTMENT OF BASIC SCIENCES, HISTOLOGY AND EMBRYOLOGY SECTION, FACULTY OF VETERINARY MEDICINE, URMIA UNIVERSITY, URMIA, IRAN
 
Abstract: 
Background: Ciprofloxacin was shown to have cytotoxic effects on testicular germ cells. Its mechanism of cytotoxic action is not fully understood. To investigate the possibility of the involvement of an oxidative stress induction in this mechanism, total antioxidant power (TAOP) in the testis was evaluated.
Materials and Methods: A number of twenty four mature male NMRI mice were used. The animals assigned into control and test groups. The test groups subdivided into low dose (206 mg/kg) and high dose (412 mg/kg) CPFX treated groups. Control animals received carboxymetyl cellulose.
All animals were treated orally for 45 days. At the end of the study the animals were sacrificed and testicular tissues were homogenized in PBS. TAOP of the testis was determined by measuring its ability to reduce Fe+3to Fe+2.The complex between Fe+2 and TPTZ gives a blue color with absorbency at 593nm.
Results: Although TAOP in the testis of low dose and high dose treated mice slightly increased but this change is not significant among three groups.
Conclusion: Oxidative stress induction by CPFX is not remarkable during 45 consecutive days. Therefore the direct action of CPFX may be involved in its mechanism of action on testicular germ cells. Meanwhile long exposure to CPFX (More than 45 days) may result in extend damages of germinal epithelium in testicular tissue which may in turn result in remarkable alterations in TAOC.
 
Keyword(s): CIPROFLOXACIN, OXIDATIVE STRESS, TESTIS, MICE
 
 
References: 
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Click to Cite.
APA: Copy

ZOBEIRI, F., & SADRKHANLOU, R., & RAZI, M., & MOKARIZADEH, A. (2012). DOES CIPROFLOXACIN EXERT SEVERE OXIDATIVE STRESS IN TESTICULAR TISSUE?. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(SUPPLEMENT 1), 137-138. https://www.sid.ir/en/journal/ViewPaper.aspx?id=272364



Vancouver: Copy

ZOBEIRI F., SADRKHANLOU R.A., RAZI M., MOKARIZADEH A.. DOES CIPROFLOXACIN EXERT SEVERE OXIDATIVE STRESS IN TESTICULAR TISSUE?. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2012 [cited 2021May15];6(SUPPLEMENT 1):137-138. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272364



IEEE: Copy

ZOBEIRI, F., SADRKHANLOU, R., RAZI, M., MOKARIZADEH, A., 2012. DOES CIPROFLOXACIN EXERT SEVERE OXIDATIVE STRESS IN TESTICULAR TISSUE?. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 6(SUPPLEMENT 1), pp.137-138. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272364.



 
 
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