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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2012 , Volume 6 , Number SUPPLEMENT 1; Page(s) 133 To 133.
 
Paper: 

AMERICAN GINSENG EFFECTS ON DAMAGE INDUCED BY CYCLOPHOSPHAMIDE IN THE NUCLEI OF RAT SPERM

 
 
Author(s):  HOSSEINI A.*, ZARE S., GHADERI PAKDEL F., AHMADI A.
 
* DEPARTMENT OF BIOLOGY, FACULTY OF SCIENCES, URMIA UNIVERSITY, URMIA, IRAN
 
Abstract: 
Background: Oxidative stress occurs when the oxidative homeostasis is damage. Excessive ROS are generated and this reaction has been proposed to produce marked damage to the structure and function of sperm.
Materials and Methods: This study was designed to investigate the protective effects of of American Ginseng against cyclophosphamide - induced damage in the rat sperm. For this experiment, the mature male rats randomly divided into four groups, seven rats in each and were treatment with cyclophposphamide (6.1 mg/ kg body weight) and ginseng (500 mg/kg body weight) for 50 days. The animals were killed one day after the last treatment. Samples of spermatozoa from the cauda epididymidis were dissected immediately. Acridin orange and Aniline blue staining used for DNA denaturation and chromatin quality assay. Significance of difference between two groups was evaluated using Tukey test.
Results: In CP-treated group percentage of double stranded DNA and mature sperms decreased in the epididymal sperm as compared with the control group, while co-administration of ginseng decreased these alterations induced by CP.
Conclusion: Alkaliting agents destroy the DNA and chromatin structure and function in sperm nuclei and this damage could be reversed by American Ginseng.
 
Keyword(s): CYCLOPHOSPHAMIDE, ACRIDIN ORANGE STAINING, ANILINE BLUE STAINING, DNA DAMAGE, SPERM, RAT
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

HOSSEINI, A., & ZARE, S., & GHADERI PAKDEL, F., & AHMADI, A. (2012). AMERICAN GINSENG EFFECTS ON DAMAGE INDUCED BY CYCLOPHOSPHAMIDE IN THE NUCLEI OF RAT SPERM. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(SUPPLEMENT 1), 133-133. https://www.sid.ir/en/journal/ViewPaper.aspx?id=272266



Vancouver: Copy

HOSSEINI A., ZARE S., GHADERI PAKDEL F., AHMADI A.. AMERICAN GINSENG EFFECTS ON DAMAGE INDUCED BY CYCLOPHOSPHAMIDE IN THE NUCLEI OF RAT SPERM. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2012 [cited 2021July27];6(SUPPLEMENT 1):133-133. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272266



IEEE: Copy

HOSSEINI, A., ZARE, S., GHADERI PAKDEL, F., AHMADI, A., 2012. AMERICAN GINSENG EFFECTS ON DAMAGE INDUCED BY CYCLOPHOSPHAMIDE IN THE NUCLEI OF RAT SPERM. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 6(SUPPLEMENT 1), pp.133-133. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272266.



 
 
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