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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2012 , Volume 6 , Number SUPPLEMENT 1; Page(s) 127 To 127.
 
Paper: 

THE EFFECT OF GINGER HYDRO-COHOL ESSENCE ON CYCLOPHOSPHAMIDE SIDE EFFECTS IN SPERMATOGENESIS PROCESSES

 
 
Author(s):  AMJADI GH.*, SABER V., TAVAKOLI M., MIRZAII A.
 
* DEPARTMENT OF BIOLOGY, ISLAMIC AZAD UNIVERSITY, SANANDAJ BRANCH, SANANDAJ, IRAN
 
Abstract: 
Background: Cyclophosphamide as an alkalizing and cytotoxic agent contributes in treatment of different kinds of cancer. It can pass the blood-brain barrier. Linking two strains of DNA in cell nucleus and breaking the inner and outer strain linkages and inhibiting RNA synthesis and as a consequence, inhibiting protein synthesis, cyclophosphamide demonstrates severe pharmacological side effects on the body. The most important cyclophosphamide side effects consist of azoospermia, reduction of gonadal hormones in hypothalamo-hypophyseal axis, reduction of sperm, infertility, cardio-vascular disorder, nephrotoxicity, bladder fibrosis and hemorrhagics cyct.
Materials and Methods: In this study, forty adult male Balb/c mice (about 20 g) were examined in four groups of ten mice. A group was received neither solotion nor the drug, control group received only the vehicle and experimental groups received cyclophosphamide (5 mg/ Kg/BW) Intraperitoneally (IP). Then hydroalcoholic ginger extract was administered (1g/Kg/BW) orally along with cyclophosphamide in 14-day period.
Results: In this study, Kruskal–Wallis test was used to analyse and calculate plasma concentrations of hypophyseal gonadotropic hormones (FSH, LH), testosterone and also spermatogenesis. Our result demonstrated that the experimental groups which received hydroalcoholic ginger extract simultaneously with the drug cyclophosphamide, significantly (p<0.05) had eleveted plasma concentrations of gonadotropic hormones and spermatogenesis related factors during receive of hydroalcoholic ginger extract.
Conclusion: This work has shown that hydroalcoholic ginger extract (1g/Kg/BW) is able to reduce pharmacological side effects of cyclophosphamide (p<0.05).
 
Keyword(s): CYCLOPHOSPHAMIDE, GINGER HYDRO-COHOL ESSENCE, SPERMATOGENESIS
 
 
References: 
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Click to Cite.
APA: Copy

AMJADI, G., & SABER, V., & TAVAKOLI, M., & MIRZAII, A. (2012). THE EFFECT OF GINGER HYDRO-COHOL ESSENCE ON CYCLOPHOSPHAMIDE SIDE EFFECTS IN SPERMATOGENESIS PROCESSES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(SUPPLEMENT 1), 127-127. https://www.sid.ir/en/journal/ViewPaper.aspx?id=272168



Vancouver: Copy

AMJADI GH., SABER V., TAVAKOLI M., MIRZAII A.. THE EFFECT OF GINGER HYDRO-COHOL ESSENCE ON CYCLOPHOSPHAMIDE SIDE EFFECTS IN SPERMATOGENESIS PROCESSES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2012 [cited 2021May15];6(SUPPLEMENT 1):127-127. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272168



IEEE: Copy

AMJADI, G., SABER, V., TAVAKOLI, M., MIRZAII, A., 2012. THE EFFECT OF GINGER HYDRO-COHOL ESSENCE ON CYCLOPHOSPHAMIDE SIDE EFFECTS IN SPERMATOGENESIS PROCESSES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 6(SUPPLEMENT 1), pp.127-127. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272168.



 
 
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