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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2012 , Volume 6 , Number SUPPLEMENT 1; Page(s) 123 To 123.
 
Paper: 

PREVALENCE OF 4977BP DELETION IN MITOCHONDRIAL DNA IN IVF FAILURE WOMEN

 
 
Author(s):  JAHANINEJAD T., PASHAIEFAR H., GHASEMI N.*, ZAIMY M.A., VARGHAIEAN Y.
 
* DEPARTMENT OF MEDICAL GENETICS, RESEARCH AND CLINICAL CENTRE FOR INFERTILITY, YAZD SHAHID SADOUGHI MEDICAL SCIENCES UNIVERSITY AND HEALTH SERVICES, YAZD, IRAN
 
Abstract: 
Background: Successful IVF process is limited by factors such as oocyte quality. Oocyte quality can be defined as its abilities to be fertilized, mature and give rise to normal offspring and it is dependent on nuclear maturation and cytoplasm maturation. Damage to mitochondrial DNA (mtDNA) has been described in oocytes in IVF failure women that decrease cytoplasmic quality because Mitochondria are essential for respiration and oxidative phosphorylation of the cell. The presence of mtDNA 4977bp deletion in many different tissues can serve as a marker of this damage. However, no attempt has been made to detect the presence of mtDNA 4977bp in blood cells of these women. This is the first report concerning the 4977bp deletion in IVF failure women.
Materials and Methods: Polymerase chain reaction techniques (PCR) were used to detect mtDNA 4977bp deletion in blood samples of 100 IVF failure women and compared with 100 women who had success IVF procedure.
Results: The prevalence of 4977bp deletion in mtDNA was 88% in IVF failure women and 45% in control samples.
Conclusion: The higher prevalence of mtDNA 4977bp deletion in patients in this study indicates that damage to mtDNA in blood cells can serve as a marker that demonstrate reduced quality of oocyte.
 
Keyword(s): MITICHONDRIAL DNA, IVF FAILURE
 
 
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APA: Copy

JAHANINEJAD, T., & PASHAIEFAR, H., & GHASEMI, N., & ZAIMY, M., & VARGHAIEAN, Y. (2012). PREVALENCE OF 4977BP DELETION IN MITOCHONDRIAL DNA IN IVF FAILURE WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(SUPPLEMENT 1), 123-123. https://www.sid.ir/en/journal/ViewPaper.aspx?id=272125



Vancouver: Copy

JAHANINEJAD T., PASHAIEFAR H., GHASEMI N., ZAIMY M.A., VARGHAIEAN Y.. PREVALENCE OF 4977BP DELETION IN MITOCHONDRIAL DNA IN IVF FAILURE WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY. 2012 [cited 2021May18];6(SUPPLEMENT 1):123-123. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272125



IEEE: Copy

JAHANINEJAD, T., PASHAIEFAR, H., GHASEMI, N., ZAIMY, M., VARGHAIEAN, Y., 2012. PREVALENCE OF 4977BP DELETION IN MITOCHONDRIAL DNA IN IVF FAILURE WOMEN. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, [online] 6(SUPPLEMENT 1), pp.123-123. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=272125.



 
 
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