Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 29 To 30.
 
Paper: 

ANDROLOGY: INSULIN EXERTS A PROSURVIVAL EFFECT ON HUMAN SPERMATOZOA VIA MECHANISMS THAT INVOLVE THE STIMULATION OF AKT PHOSPHORYLATION

 
 
Author(s):  SHOKRI S.*, PUJIANTO D.A., AITKEN R.J.
 
* DEPARTMENT OF ANATOMY, SCHOOL OF MEDICINE, ZANJAN UNIVERSITY OF MEDICAL SCIENCES, ZANJAN, IRAN
 
Abstract: 

Background: The purpose of this study was to examine the impact of Insulin (INS) on human sperm function, in light of a recent proteomic analysis indicating that these cells express the INS receptor (INSR).
Materials and Methods: We used Western blot and Immunocytochemical analyses.
Results: Immunocytochemical analyses confirmed the presence of INSR in human spermatozoa and localized this receptor to the midpiece region of the sperm as well as the neck, postacrosomal, and principal piece of the sperm tail. Western blot analyses indicated that the prosurvival effect of INS on human spermatozoa involved the stimulation of Akt phosphorylatio.
Conclusion: We conclude that INS is a prosurvival factor for human spermatozoa that prevents these cells from defaulting to an intrinsic apoptotic pathway associated with cell senescence. These findings have implications for preservation of sperm integrity in vivo and in vitro.

 
Keyword(s): INSULIN, HUMAN SPERMATOZOA, AKT PHOSPHORYLATION
 
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