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Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2011 , Volume 5 , Number SUPPLEMENT 1; Page(s) 27 To 29.
 
Paper: 

ANDROLOGY: PROGESTERONE-INDUCED REORGANIZATION OF NOX-2 COMPONENTS IN MEMBRANE RAFTS IS CRITICAL FOR SPERM FUNCTIONING IN CAPRA HIRCUS

 
 
Author(s):  MOHAMMED S., MALINI L., PRADEEP G.K.*
 
* RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY, TRIVANDRUM, INDIA
 
Abstract: 

Background: Reactive oxygen species (ROS) is generated by spermatozoa from human (Aitken and Clarkson, 1987; Alvarez et al., 1987), rat (Vernet et al., 2001), mouse (Fisher and Aitken, 1997), rabbit (Holland et al., 1982) and buffalo (Roy and Atreja, 2008). ROS initiates signaling pathways regulating key processes including capacitation (Aitken et al., 1998;Aitken et al., 1996;deLamirande et al., 1997;deLamirande et al., 1998a;deLamirande and Gagnon, 1993b;deLamirande and Gagnon, 1993a;Griveau et al., 1994;Leclerc et al., 1997), acrosome reaction (deLamirande et al., 1998b;Furuya et al., 1992;Leyton and Saling, 1989;Liguori et al., 2005;Rivlin et al., 2004) and sperm-zona pellucida interaction (Aitken et al., 1989;Aitken and Clarkson, 1987). Progesterone induces acrosmal exocytosis in capacitated spermatozoa through rapid nongenomic pathways which include calcium influx, phosphorylation of proteins and activation of several signaling cascades, which are attenuated by a countering set of nongenomic signaling triggered by estrogen (Baldi et al., 2009). Estrogens and aromatase have a direct relation with semen quality and sperm motility (Carreau et al., 2009). Nitric oxide (NO) has been shown to activate cAMP-protein kinase A pathway during capacitation and protein kinase G pathway during acrosome reaction (Herrero et al., 2003). While attempts to identify a progesterone receptor on spermatozoa are still on, human spermatozoa have been shown to possess estrogen receptors (ER) ERα and ERβ (Aquila et al., 2004).

 
Keyword(s): SPERMATOZOA, NOX, SUPEROXIDE, CAPACITATION, ACROSOME REACTION, RAFT
 
References: 
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