Paper Information

Journal:   INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY   SUMMER 2012 , Volume 6 , Number SUPPLEMENT 1; Page(s) 120 To 120.
 
Paper: 

THE ASSOCIATION OF APOLIPOPROTIEN E POLYMORPHISMS WITH RECURRENT PREGNANCY LOSS

 
 
Author(s):  ASGARI N.*, AKBARI M.T., ZARE SH., BABAMOHAMMADI GH.
 
* DEPARTMENT OF BIOLOGY, ISLAMIC AZAD UNIVERSITY, SCIENCE AND RESEARCH BRANCH, TEHRAN, IRAN
 
Abstract: 
Background: The role of apolipoprotien E polymorphisms do not diagnostic correctly in recurrent pregnancy loss etiology but Apo E has been shown to play an important role in lipid metabolism in pregnancy. We evaluated these polymorphisms in Iranian women with unexplained recurrent pregnancy loss.
Materials and Methods: 5 ml Blood were sampling from 81 women with a history of two or more consecutive spontaneous abortions and 81 women with at least two live births and not miscarriage. DNA was extracted from the leukocytes and PCR amplification of Apo E was performed.
For determining Apo E genotypes used restriction fragment length polymorphism analysis.
Results: Women with consecutive spontaneous abortions had greater significantly frequency from Apo E E3/ E4 and E4/E4 genotype (19.75%) comparing with control group (2.46%) (p=0.032).
Conclusion: Polymorphism Apo E4 may help to thrombophilic risk factors in loss of fetus during pungency. Our data supported association polymorphisms apolipoprotein E with recurrent pregnancy loss.
 
Keyword(s): APOLIPOPROTEIN E, RECURRENT PREGNANCY LOSS, APO E4 POLYMORPHISM
 
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